Thread by @giovannilandoni

We identified all sudden cardiac death occurring in Italian youngster (1-35y) and reported by media 2010-2015 under the leadership of @sozi81
pubmed.ncbi.nlm.nih.gov/33638776/
#Eriksen @IntensiveBot
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Autopsy data were available in 100/132 (75.8%) cases: an extra cardiac cause was identified in 20 (20%). Among the 61 cases with a cardiac diagnosis, 21 (34%) had hypertrophic cardiomyopathy.
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Among the 19 (19%) victims without structural abnormalities, molecular autopsy identified pathogenic variants for channelopathies in 9 cases. Ten (10%) victims had no identifiable cause
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112/132 (84.8%) victims had no prior reported symptoms, 13 (9.8%) reported intense fatigue in the 2 weeks preceding SD, 3 (2.3%) suffered from palpitations in the last 3 months, 2 (1.5%) had a history of syncope, and 2 (1.5%) a history of pre-syncope. 10 were on antibiotics.

A significantly higher number of SD occurred in winter months. 78-eight (57.6%) SD events occurred in the context of high adrenergic tone (sport n=37; physical effort n = 31; immediate post-effort recovery n=10). In 5 cases (3.8%) SD took place during intense emotional stress
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Autopsy data were available in 100 cases. Cardiac structural disease accounted for 61 (61%) of all autopsied SD cases. Extracardiac causes were identified in 20 cases (20%). There were no identified structural abnormalities in 19 (19%) of the autopsies

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