Are you looking for interesting manuscripts for your Journal Clubs in critically ill patients?

Here are 14 ideas:
➡️All RCTs
➡️All published in 2023,
➡️all @NEJM

Half of them with stat significant differences in primary endpoint (or mortality)

In order of importance

1/15 2/15

#Hydrocortisone in 800 severe community-acquired pneumonia reduced the risk of death by day 28

@NEJM

nejm.org/doi/10.1056/NE…

1/
Is it ethical to interrupt a #RCT early because the treatment group is doing too well?

In my opinion NO

Here is a practical example 2/
Adding #pyridostigmine to standard care reduced mortality among patients hospitalized for severe #COVID19

in Mexico a small study of 94 patients per group performed in hospitalized, severe (on oxygen, but not intubated) #covid19 patients

molmed.biomedcentral.com/articles/10.11…

in 1932 #oxygen was delivered subcutaneously!
with non-negligible success

#ARDS #ecmo
1/

physoc.onlinelibrary.wiley.com/doi/epdf/10.11… In 1933 #oxygen wad delivered through the peritoneal cavity and stomach
with non-negligible success

#ARDS #ecmo
2/

physoc.onlinelibrary.wiley.com/doi/pdf/10.111…

We identified all sudden cardiac death occurring in Italian youngster (1-35y) and reported by media 2010-2015 under the leadership of @sozi81
pubmed.ncbi.nlm.nih.gov/33638776/
#Eriksen @IntensiveBot
1/ Autopsy data were available in 100/132 (75.8%) cases: an extra cardiac cause was identified in 20 (20%). Among the 61 cases with a cardiac diagnosis, 21 (34%) had hypertrophic cardiomyopathy.
2/

1/
I want to thank all my colleagues for the wonderful #COVID19 research they published during these months: >200 PubMed-indexed articles from @SanRaffaeleMI @SRAnesthesiaICU @MyUniSR @azangrillo
I’ll summarize few of them in this thread. 2/
In February, before the start of #COVID19 in Europe, we suggested the use of helmet to deliver #CPAP #NIV in emergency departments. This can be a key issue to prevent future spread of respiratory pandemics in emergency departments.
thelancet.com/journals/lance…