"Infection of GF mice with the murine pathogen C. rodentium decreased vitamin D and 25D levels at 2 weeks post-infection, which was likely due to decreased absorption of vitamin D while the infected mice had diarrhea."
"Once the inflammation in the GI tract resolves homeostasis is reinstated and 25D and 24,25D levels increased at 4 weeks following C. rodentium infection. "
Look pinned tweet for FIXING da GUT biome.
The Fibroblast growth factor (FGF) SKYROCKETED in GF mice.
FGF induces the expression of CYP24A1, this gene converts:
- ACTIVE Vitamin D (1,25-dihydroxycholecalciferol)
- TO the INACTIVE, ready to be excreted VITAMIN D (calcitroic acid)