In an era where good news is in short supply, this analysis from Public Health England suggests that both Pfizer & AstraZeneca are highly effective against hospitalization with the Delta variant (after 2 doses):

1. Pfizer: 96%
2. AstraZeneca: 92%

Link: bit.ly/3iBSsn7
More details of the analysis can be found at this link, with effectiveness of Pfizer & AstraZeneca vs Alpha & Delta variants: bit.ly/3gv0uLX
Also, have a peek at the chart above & look at the effectiveness of a single dose for hospitalization....not too shabby.

This is very helpful data in support of Canada's 1st dose fast approach.

And now we are well underway for rapid follow up of 2nd doses. 🇨🇦
Last point:

Delta variant is +++ more transmissible.

It will find it's way to unvaccinated people & under-vaccinated communities.

We need to simultaneously...
1. Continue to lower barriers in Canada to vaccination.
2. Support global vaccine equity programs (COVAX).

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More from @BogochIsaac

3 Jun
More emerging data from England regarding the Delta variant (B.1.617, initially discovered in India):

-It is more transmissible
-Appears to cause more significant illness

**Vaccines are still effective but 2 doses are ++ more protective than 1**

Link: bit.ly/3vPg2R4
The takeaways are pretty clear- we need to vaccinate quickly with smart 1&2 dose strategy focusing on vulnerable individuals & communities.

Unvaccinated & undervaccinated pockets (barriers to care, choice, etc) will be vulnerable and see spikes.

But polls show most🇨🇦to be vaxed
We are doing really well in much of Canada with the vaccine rollout, so if we play it smart with 1st and 2nd dose strategies, and continue vaccinating at a rapid pace we can avoid significant impact of this variant.
Read 4 tweets
1 Jun
It looks like Canada's National Advisory Committee on Immunization (NACI) will give the green light to mixing & matching #COVID19 vaccines.

For example, those with a 1st dose of AstraZeneca may choose a 2nd dose of AZ or an mRNA vaccine.

bit.ly/3i7xkot by @adamsmiller
Mixing & matching #COVID19 vaccines may:

1. Provide more options to Canadians

2. Facilitate vaccine rollout if there are supply issues with a particular product

3. Possibly speed up rollout
Emerging data from the UK & Spain demonstrate the safety & positive immune response for mixing and matching.

France & Germany have been doing this for a while.

bit.ly/3p8VQXE
Read 4 tweets
12 May
1/ A few #COVID19 vaccine updates for Ontario:

The province will receive 250K doses of AstraZeneca this month, likely reserved for 2nd doses.

Also, it is likely that those who received 1st dose of AZ *may* get a 2nd dose of an mRNA vaccine.

(Photography: Jay Kerr @bombippy)
2/ The push for vaccine equity by pouring vaccines into 114 heavily impacted postal codes was largely successful (to date), with a higher proportion of people receiving a 1st dose in those areas compared to other neighborhoods.

Good news, but the job isn't done.
3/ Pharmacies will massively expand their administration of mRNA vaccines (Pfizer/Moderna) with an aim to have ~2500 online (in all regions) vaccinating by the end of the month.

This will significantly push our vaccination rates higher & help with the rollout.
Read 6 tweets
11 May
Ontario is pausing 1st doses of AstraZenca vaccine today as per Dr. David Williams, the Chief Medical Officer of Health,

He cites:
1. Risk of thrombosis
2. Greater supply of mRNA vaccines

Those with 1st dose of AZ will either get a 2nd dose of AZ or perhaps an mRNA vaccine.
They cite the risk of blood clots (aka VITT*) as ~1:60000, based on Ontario data.

*vaccine-induced immune thrombotic thrombocytopenia
The time frame for VITT (blood clots) to develop is between 4-28 days following AstraZeneca.

More on VITT from the Ontario Science Table 👇

bit.ly/3tDuee5
Read 5 tweets
6 May
1/ Ontario #COVID19 vaccine update (Take 2 - after twitter hack/drama):

Ontario has vaccinated >130000 people per day May 4, 5 & on track for this today too.

Over 40% of adults in the province have received at least 1 dose.

Some details on past few days & next few weeks 👇
2/ We doled out a ton of AstraZeneca when eligibility dropped from 55 to 40 yrs, but then ⬇️ supply led to ⬇️ pace of AZ vaccination.

Currently there is very little AZ administered this week following recent public discourse.

I am happy for those who received this vaccine.
3/ Equity of vaccine administration was an issue earlier in April. There is ongoing prioritization of supply to heavily impacted neighbourhoods & it's working.

This graph was when 25% of vax supply went to hot spots.

Now hot spots get 50% of supply for the next 2 weeks.
Read 11 tweets
6 May
1/ A few #COVID19 vaccine updates for Ontario:

The pace of vaccination is picking up again.

>130000 vaccines were administered May 4, and >133000 today so far.

>40% of adults in ON have received a 1st dose.

Some thoughts about the past & future weeks👇 Image
2/ People came out in droves for AstraZeneca when the age limit dropped to 40. We had a lot of AZ in the freezer at that time & now there is not much left.

(Much has been said about AZ since then. I am happy for people who received it)
3/ AstraZeneca administered via ~1400 pharmacies & primary care (family doctors & nurse practitioners) pushed our daily vaccine rate to over 130K/day. The pace slowly dropped as supply diminished.

AZ use significantly dropped yesterday & today, likely driven by public discourse.
Read 15 tweets

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