“Ovarian injury, including declined ovarian reserve and reproductive endocrine disorder, can be observed in women with COVID-19. More attention should be paid to their ovarian function under this pandemic, especially regarding reproductive-aged women.”frontiersin.org/articles/10.33…
Two studies coming to opposite conclusions about COVID-19 and ovarian function?
The first measures AMH, an indirect marker of ovarian reserve during natural cycles. The second measures a hormone inside the ovary and female steroid hormones produce by the ovary but during IVF>
The first measures AMH, an indirect marker of ovarian reserve during natural cycles. The second measures a hormone inside the ovary and female steroid hormones produce by the ovary but during IVF>
-> so it seems at this stage the gamete reserve may somehow be at risk, but the hormone production of the ovary is ?intact and the health of the follicle/ovum that has been stimulated via IVF is also OK.
What does that mean if ovarian gamete reserve is depleted? Women are born with more than enough gametes to last a lifetime, but a low gamete reserve is associated with a failure to become pregnant later in life naturally and via IVF.
“The results of this study [8] suggested that cumulus-enclosed oocytes are unlikely to be susceptible to infection by SARS-CoV-2”
In this study they looked at animal models to see if oocytes might be affected… they found probably not.
mefj.springeropen.com/articles/10.11…
In this study they looked at animal models to see if oocytes might be affected… they found probably not.
mefj.springeropen.com/articles/10.11…
Cumulus enclosed oocytes are essentially eggs that are surrounded by a layer of cells like a cloud.
Overall a mixed picture, but hints of problems. These are the findings largely after a single infection, but not necessarily vaccinated individuals. One can hope that vaccines will reduce the impact COVID19 has on fertility, but multiple episodes of COVID-19 from a young age ->
-> does not look advisable for female reproductive health. Severity of recurrent COVID-19 infections may wax and wane depending on vaccine coverage and variant resistance.
There are other effects apart from female gamete health including implantation, placental issues and foetal demise/prematurity that may be impacted as detailed in the article.
There is one case report of an ovary becoming gangrenous due to a clot in the vein that drains it in a pregnant patient with COVID19.
Serious concerns have already been raised and detailed in seperate threads regarding male sexual function and fertility also.
Serious concerns have already been raised and detailed in seperate threads regarding male sexual function and fertility also.
Overall, recurrent endemic waves of COVID19 may impact a populations ability to reproduce. Further long term work could be done to investigate this… but you know me… I advise stopping the experiment.
#TargetingZero🦠
#TargetingZero🦠
Thanks to @UK_Centrist and @0bj3ctivity for inspiring me to do some homework on this today.
Correction epidemic
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