Top question asked right now: what to do about J&J 1-shot #COVID19 vaccine & rise of #DeltaVariant? Not medical advice: lots of immunologists are hypothesizing & predicting mixing vaccines of different types could yield equal/better response. Trials TBD.🧵
bloombergquint.com/coronavirus-ou…
2) “If you can mix and match, it’s going to look better, something that immunologists have known for decades” said Danny Altmann, professor of immunology. “I’d bet my house on working hypothesis that it’s doable and would produce immunity that’s at least as good if not better.”
3) “After years of reading research on mixing vaccine types -- known as heterologous prime-boosting -- Morgon concluded that getting one dose of the AstraZeneca shot, and another from Moderna Inc.’s or Pfizer Inc.’s newer messenger RNA technology would pack the most punch.”
4) “For now, taking 2 different shots is likely to remain the exception rather than the rule, as some countries explore the approach. France, Spain, Finland, Sweden, Norway, & Canada are mixing vaccines or considering it among some age groups who’d had Astra shot for first dose”
5) “Early research appears to back the approach. A study of almost 700 people in Spain showed that those who received a second dose of Pfizer’s vaccine after a first Astra shot saw their neutralizing antibodies climb sevenfold, significantly higher than two Astra doses.”
6) “A small trial in Germany suggested that mixing Astra and Pfizer shots could trigger antibody responses almost four times higher than a two-dose course of the Pfizer vaccine” medrxiv.org/content/10.110…
7) “In the U.S., the NIH recently launched a trial to evaluate the method in humans, suggesting an approval for the general population could still be several months away. One drawback is that the approach appears to cause more side effects such as fevers, chills and headaches”
8) “Because AZ shot isn’t yet approved in U.S., Enright got Johnson & Johnson’s vaccine, which uses similar technology but is intended for a one-dose regimen. He followed up 3 months later with dose of the vaccine developed by Pfizer, & didn’t have any significant side effects.”
9) “They asked ‘why are you getting a booster?’ And I said ‘this is what I do for a living.’ And they said, ‘ok,’” said Enright. “I think we’ll get a stronger immune response, a stronger protection against existing and variant strains and likely a longer immunity.”

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More from @DrEricDing

19 Jun
📍Serious—Biden warns #DeltaVariant “will leave unvaccinated people even more vulnerable. It is more easily transmissible, potentially deadlier & particularly dangerous for young people. if you have 1 shot, get 2nd shot as soon as you can” #COVID19
cnbc.com/2021/06/18/bid…
2) #DeltaVariant is the most serious worrisome variant known to date— its leaps and bounds faster transmission than other variants. See new study thread 🧵
3) just this week, CDC (at last) declared and upgraded the warning level of #DeltaVariant a “variant of concern”
Read 4 tweets
19 Jun
Untold heroes who defeated polio—to prove his vaccine, Jonas Salk needed 400,000 glass tubes🧪 w/ temperature sensitive “Henrietta Lacks cells” (from a Black woman)—cultivated by Black scientists at Tuskegee, who made 10,000 vials/week.

By @ainissaramirez scientificamerican.com/article/hidden…
2) researchers needed special “HeLa cells”, the living line of cells that were taken without permission from a Black patient named Henrietta Lacks decades earlier. After blood draw from vaccinated patient, it was placed in a glass dish along with HeLa cells & small dose of polio.
3) “With those items, a microscopic—and deadly—battle commenced. In the dish, the poliovirus tried to attack the HeLa cells. If there were enough of the proper antibodies in the patient’s blood, however, they blocked the virus from causing any harm.
Read 17 tweets
18 Jun
I cry for South America—Paraguay, Suriname, Argentina, Uruguay, Colombia, Brazil & Peru are suffering a silent decimation by #COVID19 unlike anywhere else. Even in 7th-placed Peru, deaths per million is 9.12–more than 3x India. Countless families lost. 😢
theguardian.com/global-develop…
2) “There’s really so little support from the government – it’s a disaster. They should have prepared for all this from the start of the pandemic.”
As she spoke, two women collapsed in the hospital’s entrance, uncontrollable tears announcing another coronavirus death in Paraguay.
3) “We needed intensive care yesterday for my dad and there wasn’t any. There just isn’t any.”
On Wednesday this week, Paraguay registered 18.09 deaths per million, compared with 2.71 in India, 2.2 in South Africa, 1.01 in the US, and 0.14 in the UK.
Read 5 tweets
18 Jun
Not good—a #COVID19 outbreak kills 2 staffers in @ManateeGov Florida & hospitalized 3 others, forcing closure of building. 1 of 4 hospitalized staff died. 1 other died at home just 1 day after doctor visit. All were “non-elderly” staff.🧵
bradenton.com/news/coronavir…
2) Unclear vaccination status — “One staffer in the department who worked closely with the other five and didn’t contract the coronavirus was vaccinated. All five who contracted the virus had a sore throat as their initial primary complaint.”
3) “Both staffers who have died, a man and a woman, were in their 50’s. Those who were hospitalized were as young as their late 30’s, according to Hopes, causing him concern that we could be seeing one of the stronger variants in these cases.”
Read 9 tweets
18 Jun
Over 350 medical workers have caught #COVID19 in Java, Indonesia 🇮🇩despite being vaccinated with Sinovac’s CoronaVac—dozens of HCW even hospitalized, officials say, as concerns grow on vaccine efficacy versus #DeltaVariant, believed to be driving cases.🧵
reuters.com/world/asia-pac…
2) Most of the workers were asymptomatic and self-isolating at home, said Badai Ismoyo, head of the health office in the district of Kudus in central Java, but dozens were in hospital with high fevers and falling oxygen-saturation levels.
3) Kudus, which has about 5,000 healthcare workers, is battling an outbreak believed to be driven by the more transmissible Delta variant, which has raised its bed occupancy rates above 90%.
Read 11 tweets
18 Jun
📍SLOW ACTION ENDANGERS HEALTH & ECONOMY—Why does an epidemic take hold? #DeltaVariant surging—but what if the CDC had warned or acted earlier? Epidemiologists say we can likely prevent a big outbreak if just a cases, but harder if hundreds or 1000’s of cases… thread 🧵 #COVID19
2) And early fast action buys us precious time for vaccinations if we acted fast. Even if spread was inevitable, we could prevent the worst of it if we bought ourselves more time to fully vaccinate and prepare for the #delt
3) In terms of travel restrictions, we all acted much too late— epidemiologists and experts were warning about India in early April already. Yet govts didn’t act until mostly late April. One major country’s CDC didn’t act until May. 👀
Read 7 tweets

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