1/8 The latest version of our paper showing the limited impact of the SARS-CoV-2 variants on T cell reactivity is out today in @CellRepMed @aetarke @Alba_Grifoni @profshanecrotty @Dani6020 @ljiresearch cell.com/cell-reports-m…
2/8 The original study was available on march 01 2021 in biorxiv biorxiv.org/content/10.110….
3/8 Since the BioRxiv preprint, we have strengthened our conclusions by nearly tripling the # of donors tested and adding an additional cohort of unexposed donors. What do we show?
4/8 We tested naturally infected (ancestral strain) and vaccinated individuals and found that CD4 and CD8 T cells still recognize the 4 prominent variants of concern B.1.1.7, B.1.351, P.1 and CAL.20C.
5/8 CD4 and CD8 T cells responses to the variant strains tested remain largely unaffected (more than 80% preserved on average in all cases).
6/8 We think this is really good news. This is true for both COVID survivors and people who received the Moderna and Pfizer vaccines.
7/8 Since our initial preprint, 2 additional studies by @Barouchlab and @RorydeVires have confirmed that the T cell reactivity is largely unaffected by the variants nature.com/articles/s4158… immunology.sciencemag.org/content/6/59/e…
8/8 We will continue monitoring T cell responses to new variant strains. Currently working on studying a larger group of variants of concern, including the delta variant.
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