Something for believers in mucosal immunity & nasal spray vaccines, like @jacquesenboit. If I understand correctly, #SARS2-specific dIgA might be the best biomarker of current/recent #SARS2 infection.
I meant, fellow believers. Because, from the start I thought the way to stop a worldwide raging pandemic with a highly infectious airborne respiratory virus is not an intramuscular vaccine (attenuates outcomes) but a nasal spray vaccine (stops the spread).
Ups, weirdly, I just tried to search & find the old tweets I wrote about nasal vaccines to no avail, but most appear deleted (I know cause I copy my tweets, dated, on hard drive)?! Are nasal spray vaccines now a conspiracy theory too, forbidden to mention? frontiersin.org/articles/10.33…
"Our findings demonstrate that systemic HuNAb suppresses SARS-CoV-2 replication and injury in lungs; however, ROBUST VIRAL infection in NASAL turbinate may OUTCOMPETE the ANTIBODY with significant implications to subprotection, reinfection, and vaccine." cell.com/cell-host-micr…
All of these kind of studies are out for a year, and could have been known by anyone paying attention. This phase of the pandemic we are facing was predictable last year. We are now placed in a tough predicament as governments declare: suck it up, let it rip & live with #SARS2.
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Since the UK decided to experiment with living with #COVID19 by dropping NPIs in the face of an upward wave, it's now more than ever important to look at data. I can't stand the bickering & manipulation by both sides, so I'll try to look at it objectively. bloomberg.com/news/articles/…
All numbers used here are from GOV.UK summary & this analysis ends on 29 June, the last day with hospitalization info. Charts are logarithmic, adjusted to match a 100 for both cases & hospitalizations. coronavirus.data.gov.uk
1st, let's compare daily numbers with 7-day averages. Last year, cases bottomed in July & slowly increased to 1000, while at the same time, hospitalizations continued to decrease through the summer, until September. Then, they synchronized again, with a usual hospitalization lag.