1/5
@BretWeinstein claims we know how IVM works because it binds the SARS2 spike protein. Is he correct? No.
The only evidence we have for IVM binding the spike comes from a computer modeling:
@BretWeinstein claims we know how IVM works because it binds the SARS2 spike protein. Is he correct? No.
The only evidence we have for IVM binding the spike comes from a computer modeling:
https://twitter.com/clif_high/status/1408507154097573889
2/5
The computer model predicts that IVM binds to L91 of the 1300 aa spike AND that it binds to the ACE2 receptor.
ncbi.nlm.nih.gov/pmc/articles/P…
The computer model predicts that IVM binds to L91 of the 1300 aa spike AND that it binds to the ACE2 receptor.
ncbi.nlm.nih.gov/pmc/articles/P…
3/5
Where is L91 located in the spike? In NTD (blue), which it pretty far from the RBD (green) that interacts with the ACE2 receptor.
But it is also predicted to bind to the receptor itself! Isn’t that why people think the spike is toxic, as it interferes with ACE2 signaling?
Where is L91 located in the spike? In NTD (blue), which it pretty far from the RBD (green) that interacts with the ACE2 receptor.
But it is also predicted to bind to the receptor itself! Isn’t that why people think the spike is toxic, as it interferes with ACE2 signaling?
4/5
Also, even if that WAS the mechanism of IVM action, you would need it to be present in the blood in significant concentrations, which is NOT possible with a weekly dosing regimen, as IVM half life is 18 hours.
Also, even if that WAS the mechanism of IVM action, you would need it to be present in the blood in significant concentrations, which is NOT possible with a weekly dosing regimen, as IVM half life is 18 hours.
5/5
Finally, let me remind you that this is just a computer modeling study and that we did not get any experimental confirmation of these predictions. But they are largely irrelevant anyways, for the reasons outlined above.
Finally, let me remind you that this is just a computer modeling study and that we did not get any experimental confirmation of these predictions. But they are largely irrelevant anyways, for the reasons outlined above.
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