QUICK NE CASE UPDATE BEFORE FOOTBALL:

Cases in NE continuing to grow fast and much higher than all other regions. Image
It's not just testing - similar pattern seen for positivity rates. Image
The hotspots are centred around Newcastle / Sunderland area and Hartlepool Image
There seems to be some (unsruprising) correlation with lower vaccination rates - likely due to age profile of population (e.g. student areas will have lower vax rates).

1st dose coverage below - lighter colour = lower vax rate. Image
You can see really high numbers from Monday this week in the NE hotspots Image
And Monday's numbers in the NE also very high overall (compared to some other regions).
Yorkshire showing big recent increase too though. Image
That said, other regions are catching up in terms of growth rate- SE, East of England, E & W Midlands all have growth rates similar to NE over last week - but from much lower base.
Not clear why NE so much higher - most likely a combo of factors and some bad luck.

Unfortunately very little sequencing data available for NE, but what there is, is Delta.
What we do know is that cases are highest in 15-30 year olds - but also very high now in 30-50 yr olds - similar to last November wave. And rising fast in those and older age groups. Image
This is translating to very rapid hospitalisation growth in the NE as well.

And sadly this will get worse over next few weeks given rapid recent case increases. Image
The *overall* better (?!) news is that England growth rates have slowed a bit from over 65% week on week to about 50% this week.

This is still very high, but much better than it was!! /END

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More from @chrischirp

9 Jul
NEW VARIANT alert THREAD:

COG UK, which sequences positive covid cases in UK just released its latest update.

The number of Delta Plus (AY.1) variant cases increased from 44 (latest PHE update gov.uk/government/pub…) *to 2,144*.

sars2.cvr.gla.ac.uk/cog-uk/

So what? 1/9 Image
Well, Delta Plus is Delta with an extra mutation called K417N.

India has designated it a variant of concern (as have we) but we don't know much about it - it *might* have increased transmissibility but very little data.
webmd.com/lung/news/2021…
bbc.co.uk/news/world-asi…
2/9
Analysing today's COG data you can see that Delta Plus rapidly increased in June from nothing to almost 3% of sequenced cases in England

Last 2 weeks has flattened off BUT 3/9 Image
Read 9 tweets
5 Jul
I was hoping to dig through Sanger variant data for NE today but only 4% of NE June's cases & 19% of May cases have been sequenced so far (compared to e.g 70% & 23% for NW respectively).

This is the lowest of any region for both months - not sure why but it's frustrating. 1/2
It's likely NE rapid rise is a combination of the various factors people have suggested: high deprivation, lower January peak, football, students... but none on its own is unique to NE & start of rapid rise predated football.

But I'd like to be surer it's not a bad variant. 2/2
PS so far, NE looks like just a Delta rise - over 95% of sequenced cases in June were Delta. But as I said, small numbers.
Read 4 tweets
3 Jul
THREAD: Something weird is happing in the North East - as mentioned today by @Unusual_Times and it came up briefly in the @IndependentSage briefing today.

But I've looked a bit closer and it's a bit worrying. 1/5
Their cases are rising very rapidly - as are their positivity rates and hospitalisation rates. The last two days are likely undestimates as well due to some test results still to come back. 2/5
If we look at cases on a log scale (where exponential growth is a straight line. Steeper straight lines mean faster growth), we can see that NE starts growing faster beginning of June.

SW grew that fast too - prob due to combo of half term + G7 - but has slowed down since. 3/5
Read 6 tweets
2 Jul
THREAD: Where are we in UK with cases, where are we going and should we care?

TLDR: nowhere good, somewhere worse, absolutely yes.

1/24 (yes, I know, another long one. Still worth a read I hope!)
We are at almost 30,000 daily cases again - numbers last seen in mid December.

Cases are climbing steeply. 2/24 Image
They are climbing in all nations now - over the last week growth in all nations was about 70%.

This is clearer when looking at the same plot on a log scale (2nd chart).

It's not just testing- positivity is rising too (note that positivity chart only to 26 June) 3/24 ImageImageImage
Read 25 tweets
29 Jun
THREAD on vaccination, population immunity & children.

TLDR: Current gov policy seems to be getting to population immunity by vaxxing adults and infecting kids.

Are we really saying better to infect millions of kids than to a) prevent them getting it and b) vax them? 1/8
Ultimately we want to control covid by high percentage of population being immune.

With Delta we probably need 85%+ of population immune (assuming R0~7). Children are 21% of English population.

You *cannot* get to 85% without high proportion of children being immune. 2/8
The top bar shows breakdown of English popn by age - adults are 79% of population. Even if vax were perfect & all adults were vaxxed, you'd still need many children to be immune too.

Bottom bar shows 1 way of getting to 85% popn immunity with optimistic adult vax coverage. 3/8
Read 9 tweets
28 Jun
THREAD Confirmed cases in Scotland are as high as they've ever been (3.2K reported today) - and it's not just more testing, as positivity rates are over 10% and as high as they've been since the January 2021 peak.

Week on week cases have more than doubled.
Hospital & ICU occupancy are rising but still much lower than January's peak - obviously a very good thing.

This is because of vaccination and because infections are mainly in young people (also partly cos of vax)
But rapid recent increases have not yet fed through to hospitalisations - so hospitalisations will go up over next 2 wks.

Also, 20-30% of people infected will likely end up with long covid - with maybe 15% having it severely affect their daily lives
imperial.ac.uk/news/224853/ov…
Read 11 tweets

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