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Prof Peter Hotez MD PhD Profile picture
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11 Jul, 4 tweets, 2 min read
Many thanks ⁦@Christi_Paul⁩ for hosting me ⁦@NewDay⁩ Sunday, as we watch the delta variant spread from Missouri and Arkansas into the Deep South where vaccination coverage is low. We’re going to lots of hospitalizations and long-haul COVID19 in the coming weeks
Regarding long haul COVID19 or PASC I’ve been flagging this @medrxivpreprint from @UniofOxford looking at grey matter brain 🧠 degenerative disease following COVID19 affecting some areas that resemble cognitive decline in aging or even Alzheimer’s medrxiv.org/content/10.110…
Remember, COVID19 PASC is not rare, up to 10-30% of recovering Covid patients. We’re learning that the SARS-2 coronavirus is a neurotropic virus. So when those seeking to downplay Covid quote low mortality rates among young people, I say, hey that’s just the tip of the iceberg
I really worry with delta infecting so many unvaccinated young adults and adolescents in the South, these neurological consequences could haunt us for a long time

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More from @PeterHotez

Prof Peter Hotez MD PhD Profile picture
12 Jul
Many thanks ⁦@ErinBurnett⁩ for hosting me ⁦@OutFrontCNN⁩ I explained why a 3rd immunization of mRNA vaccines may eventually be needed to protect against new variants, although not necessarily the delta variant. But there was one surprise tonight… Image
I was surprised there was no comment on individuals receiving immunosuppressive therapy for solid organ transplants, or BMT, CAR-T etc. There is some evidence of added benefit for a third immunization to increase virus neutralizing antibodies and expand seroconversion
For example acpjournals.org/doi/10.7326/L2…
Read 5 tweets
Prof Peter Hotez MD PhD Profile picture
10 Jul
This is just beginning in the US, starting with the state of Missouri. But if the US goes the same direction as Europe, many unvaccinated people in the US South (and elsewhere where vaccination coverage is low) should expect to become infected with delta COVID19 in the coming wks
I mean, what about this makes the far right in America 🇺🇸 think this will go well here? What do they think is going to happen this summer in low vaccine coverage areas of the South?
Making my "wish list" now of specific individuals I would like to meet in person and plead with them to get behind vaccinating the South, Mountain West and other vulnerable areas of the country asap....here goes:
Read 10 tweets
Prof Peter Hotez MD PhD Profile picture
10 Jul
Many thanks ⁦@andersoncooper⁩ for hosting me @AC360 tonight. I’ve been saying that eventually we’ll likely need a 3rd mRNA immunization to further increase virus neutralizing antibodies and cellular immunity to provide more robust protection and resilience against variants
But the publicly available evidence that protection is waning vs delta variant as per Pfizer PR not strong, and evidence from UK elsewhere also indicates pretty robust immunity. So while yes we will eventually need a 3rd immunization based on current data may not be necessary now
Also not clear to me why we would do a booster through an EUA mechanism? There is urgency to get the 3 current US COVID19 vaccines through the full approval mechanism, and then the booster through traditional processes. Otherwise we risk eroding public confidence
Read 5 tweets
Prof Peter Hotez MD PhD Profile picture
8 Jul
This might make sense but EUA is not a slam dunk. Evidence that protective efficacy really wanes based on limited and variable studies, and virus neutralizing ab levels don’t tell us what’s happening with memory cells. Also there’s the global equity issue apnews.com/article/europe…
So I recognize that a 3rd immunization would really crank up VNA and that’s a good thing for resilience to the variants of concern, but there will other considerations. It will be interesting to see if FDA says yes or will require a full on study for the EUA.
It would also be good to look at whether we could achieve more durable protection using a prime boost approach with our recombinant protein vaccine? In other words 2 doses of Pfizer followed by ours. But so far not much interest from the United States
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
8 Jul
“Perplexed”? Really? Someone please purchase a television, a cable connection, and internet access for the Senator, so he learns what his colleagues have been up to.
Some things you may have missed, Senator
Read 6 tweets
Prof Peter Hotez MD PhD Profile picture
7 Jul
It’s with my profound grief and sadness to learn of the unexpected and sadden loss of my lifelong friend, Joe Pava. We grew up together in West Hartford CT, headed up there now for the funeral tomorrow. His passions were books, music, and his brilliant wife, Karen. No words.
Joe with his wife Karen and my sister Liz when I was honored by @BnaiBrith in 2017
Sudden, not Sadden, Freudian slip there
Read 4 tweets

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