It’s with my profound grief and sadness to learn of the unexpected and sadden loss of my lifelong friend, Joe Pava. We grew up together in West Hartford CT, headed up there now for the funeral tomorrow. His passions were books, music, and his brilliant wife, Karen. No words.
Joe with his wife Karen and my sister Liz when I was honored by @BnaiBrith in 2017
This might make sense but EUA is not a slam dunk. Evidence that protective efficacy really wanes based on limited and variable studies, and virus neutralizing ab levels don’t tell us what’s happening with memory cells. Also there’s the global equity issue apnews.com/article/europe…
So I recognize that a 3rd immunization would really crank up VNA and that’s a good thing for resilience to the variants of concern, but there will other considerations. It will be interesting to see if FDA says yes or will require a full on study for the EUA.
It would also be good to look at whether we could achieve more durable protection using a prime boost approach with our recombinant protein vaccine? In other words 2 doses of Pfizer followed by ours. But so far not much interest from the United States
“Perplexed”? Really? Someone please purchase a television, a cable connection, and internet access for the Senator, so he learns what his colleagues have been up to.
Many thanks @Boris_Sanchez for hosting me: we’re now seeing COVID surge this summer (as predicted) in areas where there’s the one-two punch of low vaccination and high delta. That’s why we’re seeing COVID re emerge in MO AK WY with more to follow.
"In comparison to SOC or placebo, IVM did not reduce mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease. IVM did not have an effect on AEs or severe AEs. IVM is not a viable option to treat COVID-19 patients" academic.oup.com/cid/advance-ar…
IVM is a great drug...for river blindness, strongyloidiasis, and scabies. Through my advocacy for mass/preventive Rx packages for neglected tropical diseases #NTDs in the early 2000s, my name is associated with providing IVM access to tens of millions of people living in poverty
But as an antiviral for clinical use, I've not seen compelling data, as the new paper I provided from Clinical Infectious Diseases - one of the top journals in our field - appears to confirm. Possibly there is an indication buried somewhere in there, and I'm open, but so far no
My colleagues say: 1. Vladimir Putin is the world’s wealthiest man. 2. He seeks to consolidate power by destabilizing Western Democracies. 3. He is clever, achieves gains through multiple disinformation approaches, including the GOP 4. This requires targeting US scientists
And (for full transparency) I present zero evidence for this, but it sounds plausible. Certainly from the language and aggression against me, family. But I think there’s enough there we should investigate
My opinion, and nothing more than opinion, is that there is a sinister link between Putin, Russia, and the disinformation targeting me other scientists, from far right members of our US Congress, and conservative news outlets
1/3 Many thanks @PoppyHarlowCNN @jimsciutto for hosting me, we spoke about the heterogeneity of COVID19 transmission across the nation, a consequence of 2 major factors: levels of vaccination and delta variant. Therefore CDC recs should be fine tuned accordingly
2/3 for example risk is especially high right now in Southern Missouri due to low vaccine coverage and high delta variant. CDC might consider presenting a “force of infection” map for the nation. So for example even if vaccinated, if I’m indoors I might still mask where FOI high
3/3 other important point, it’s not too late to get vaccinated, in areas of low vaccine coverage and delta that FOI will seek you out and you will become infected