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Prof Peter Hotez MD PhD Profile picture
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8 Jul, 6 tweets, 2 min read
“Perplexed”? Really? Someone please purchase a television, a cable connection, and internet access for the Senator, so he learns what his colleagues have been up to.
Some things you may have missed, Senator
msnbc.com/rachel-maddow-…
esquire.com/news-politics/…

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More from @PeterHotez

Prof Peter Hotez MD PhD Profile picture
10 Jul
Many thanks ⁦@andersoncooper⁩ for hosting me @AC360 tonight. I’ve been saying that eventually we’ll likely need a 3rd mRNA immunization to further increase virus neutralizing antibodies and cellular immunity to provide more robust protection and resilience against variants Image
But the publicly available evidence that protection is waning vs delta variant as per Pfizer PR not strong, and evidence from UK elsewhere also indicates pretty robust immunity. So while yes we will eventually need a 3rd immunization based on current data may not be necessary now
Also not clear to me why we would do a booster through an EUA mechanism? There is urgency to get the 3 current US COVID19 vaccines through the full approval mechanism, and then the booster through traditional processes. Otherwise we risk eroding public confidence
Read 5 tweets
Prof Peter Hotez MD PhD Profile picture
8 Jul
This might make sense but EUA is not a slam dunk. Evidence that protective efficacy really wanes based on limited and variable studies, and virus neutralizing ab levels don’t tell us what’s happening with memory cells. Also there’s the global equity issue apnews.com/article/europe…
So I recognize that a 3rd immunization would really crank up VNA and that’s a good thing for resilience to the variants of concern, but there will other considerations. It will be interesting to see if FDA says yes or will require a full on study for the EUA.
It would also be good to look at whether we could achieve more durable protection using a prime boost approach with our recombinant protein vaccine? In other words 2 doses of Pfizer followed by ours. But so far not much interest from the United States
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
7 Jul
It’s with my profound grief and sadness to learn of the unexpected and sadden loss of my lifelong friend, Joe Pava. We grew up together in West Hartford CT, headed up there now for the funeral tomorrow. His passions were books, music, and his brilliant wife, Karen. No words.
Joe with his wife Karen and my sister Liz when I was honored by @BnaiBrith in 2017
Sudden, not Sadden, Freudian slip there
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
5 Jul
Many thanks @Boris_Sanchez for hosting me: we’re now seeing COVID surge this summer (as predicted) in areas where there’s the one-two punch of low vaccination and high delta. That’s why we’re seeing COVID re emerge in MO AK WY with more to follow.
Here’s my prediction @thedailybeast thedailybeast.com/covid-19-is-ri…
FYI to get timely information on where delta lives I go to @scrippsresearch the outbreak.info website
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
4 Jul
"In comparison to SOC or placebo, IVM did not reduce mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease. IVM did not have an effect on AEs or severe AEs. IVM is not a viable option to treat COVID-19 patients"
academic.oup.com/cid/advance-ar…
IVM is a great drug...for river blindness, strongyloidiasis, and scabies. Through my advocacy for mass/preventive Rx packages for neglected tropical diseases #NTDs in the early 2000s, my name is associated with providing IVM access to tens of millions of people living in poverty
But as an antiviral for clinical use, I've not seen compelling data, as the new paper I provided from Clinical Infectious Diseases - one of the top journals in our field - appears to confirm. Possibly there is an indication buried somewhere in there, and I'm open, but so far no
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
3 Jul
My colleagues say:
1. Vladimir Putin is the world’s wealthiest man.
2. He seeks to consolidate power by destabilizing Western Democracies.
3. He is clever, achieves gains through multiple disinformation approaches, including the GOP
4. This requires targeting US scientists
And (for full transparency) I present zero evidence for this, but it sounds plausible. Certainly from the language and aggression against me, family. But I think there’s enough there we should investigate
My opinion, and nothing more than opinion, is that there is a sinister link between Putin, Russia, and the disinformation targeting me other scientists, from far right members of our US Congress, and conservative news outlets
Read 4 tweets

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