Everything you need to know about the Delta Variant

Quick summary thread 🧵
unchartedterritories.tomaspueyo.com/p/delta-varian…
Cases are exploding around the world
Mostly due to Delta
It spreads so fast because R0 is much higher than before. From ~2.7 to ~4-9. That difference is HUGE, and can make COVID more transmissible than smallpox.
Yet it's killing less because vaccines are protecting the elderly. The young are those getting infected.
But the young don't die as much.
Vaccines are really good, even against Delta. mRNA ones reduce hospitalization and death by ~93%.

So get vaccinated.
But they only protect ~65% against symptomatic infection.

With an R of, say, 8, the herd immunity threshold would go up to ~85%. With a vaccine that only protects 65% of ppl against infection, *even vaccinating all the population would not stop the virus*
That doesn't account for Long COVID, which affects ~1/8 symptomatics. So what can we do?
1. If you're an individual, if you're vaccinated, you're good. Be cautious though. Your likelihood of death is~0.14%, assuming you will get exposed.

If you're not vaccinated, get vaccinated asap. 2 shots ideally. Mix-and-match if you can.
2. If you're a community leader:
Vaccinate, vaccinate, vaccinate. The lives of your community depend on it. Any vaccine that works is better than none. If people are opting out, try to lure them in.
Also, keep Delta at bay as much as you can while vaccinations proceed. An elimination strategy will be best. Good border fences and test-trace-isolate programs are your best tools. Super-spreader events should still be avoided. Masks indoors and in crowds. Great ventilation.
3. If you're in charge of vaccine policy, vaccinate everybody you can. Approve mix-and-match.

More details in the article
unchartedterritories.tomaspueyo.com/p/delta-varian…

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More from @tomaspueyo

12 Jul
Vaccines: mix them.

We have to realize that the only reason why we mandate 2 doses of some vaccines is because that's what we tested and it turned out to work.

It doesn't mean 2 doses is ideal.
It doesn't mean that amount is ideal.
It doesn't mean 3 weeks apart is ideal.
The question then is: what is ideal?
We can't test all combinations w/ RCT (randomized controlled trial). It's hard enough to just test vaccines.

We can rely on priors and new evidence.
Priors: the world is messy. The variants present during a RCT are not all the variants ppl will face. Things evolve.

Which combination do you think will be more effective: one that prepares you twice to the exact same enemy, or one that shows you different enemies?
Read 13 tweets
11 Jul
COVID prevalence in Europe
Left: July to November 2020
Right: July 2021 so far
To all the countries that have eliminated it in Europe: Don't let your guard down. Keep a fence on your borders. Race to vaccinate. Keep improving test-trace-isolate programs. The speed & gravity of the Delta wave will depend on it.
Read 4 tweets
9 Jul
Should everybody learn to speak English? Yes:
1. Network effects of a common language are stronger than ever in History
2. It's the 1st time these are global
3. English is the most spoken / written language & the fastest growing

Only one thing can prevent this

Thread 🧵
1k years ago, ppl mostly spoke with those around them. Little need for a lingua franca. In Europe, Latin was enough, learned by the Church and the elites.
After the printing press, suddenly you can learn & communicate w/ ppl far away. Incentive to understand each other ➡️ languages appear around the dialects most published. In Europe you go from a gradient of languages to German, English, French, Spanish...
Read 19 tweets
9 Jul
One of the key features ppl traditionally miss about history: the network effects that drive it, and their consequences for today

Thread 🧵
1. The better the initial natural resources—especially food—the faster your population grew.
2. The more natural resources, the higher the incentive to develop more tech to harness them
Read 13 tweets
5 Jul
The main reason why the US is the power it is today is because of immigration.

The main reason why the US is dwindling is because of lack of immigration.

The only thing that can reverse the US' decline is allowing massive immigration.

Thread. 🧵
The history of the US' rise is the history between 1850 and 1950.

GDP = population * GDP per capita.

For all the rhetoric about how the US is such a special country, it's not that much more productive than other Western democracies.
And as you might know if you follow me, I argue that this higher GDP per capita comes more from its geography than anything else.

unchartedterritories.tomaspueyo.com/p/world-chessb…
Read 12 tweets
24 Jun
S curves are everywhere. Learning to identify them is a superpower

They're how epidemics evolve
How memes spread
How investment unfold
How businesses grow
How muscles contract
How technology us adopted
How animation flows
How popcorn explodes
How ice melts
How water evaporates
How countries are formed
How magnets snap
How atoms spin
How transistors change their charge
How ppl get promoted
How they succeed
How they're fired
How they're born
How they die
We don't always recognize them because, depending on where we are on an S curve, it might not look like one.

It might look line a horizontal line
Or a vertical one
Or an oblique one
Or an exponential
Or a noisy surve
Read 15 tweets

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