Really important study looking at daily sampling of early SARS-CoV-2 infection in 60 individuals, focusing on viral shedding for up to 14d. medrxiv.org/content/10.110…
Lots of stuff to learn here:
Lots of stuff to learn here:
1. Sore throat, runny nose, and muscle aches had strongest relationship with positive viral culture.
2. For most individuals, nasal VL > saliva VL and viral shedding peaks at least 1d earlier in saliva vs. nasal.
3. Viral load is not perfectly predictive of infectiousness.
2. For most individuals, nasal VL > saliva VL and viral shedding peaks at least 1d earlier in saliva vs. nasal.
3. Viral load is not perfectly predictive of infectiousness.
*4. Massive (i.e. 40-fold) heterogeneity in individual level infectiousness, with imperfect correlation with age. This means that features of the "the spreader" can be a very important contributor to superspreading.
5. No clear explanation of increased transmissibility of VOCs.
5. No clear explanation of increased transmissibility of VOCs.
These kinds of studies help provide us insight into transmission dynamics, and suggests that the earlier salivary viral peak might prove helpful diagnostically (throat samples?).
They also tell us we have much to learn on incr. transmissibility of VOCs.
They also tell us we have much to learn on incr. transmissibility of VOCs.
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