Here's a fun "conditional probability" example: Both vaccination rates and hospitalization/deaths are very left skewed, while the US population is right skewed. What effect does this have look at vaccine efficacy, but normalize by current hospitalizations, because you're a hack?
Let's assume for simplicity the weighted average of vaccines is 90% effective, and also flat across age groups. Conditioned *only on dath/hospitalization*, 35% of all deaths will still be fully vaccinated individual, and 24% of hospitalizations will be vaccinated. Not great!
But considered relative to *the entire population*, while deaths are still split evenly between vaxxed and not, there's so many protected in the vulnerable group, the population deathrate dropped by a factor of 7. Consider that graph, with a 0% vaxxed population for comparison:
In other words, breathless stories about how "X% of people who had Bad Thing happen were vaccinated!!" tell you nothing about how effective vaccines are, because you would expect a large chunk of Bad Things to happen to the vaxxed because they're 5-10x the size of the others now.

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More from @quantian1

18 Jun
Alright losers, it’s Krugposting time. I have had nothing but coffee and cigarettes all day in preparation for this meal. Starting off with a sea bass sando w/ green tea, then a grilled maitaake chawanmushi, and then a tuna inari pocket.
A DIY wagyu taco in pickled daikon, plus an action shot; octopus with hijiki seaweed salad, and butter poached white asparagus
Tempura course time. Starting with spring onion and maitake, then salmon and sea add, then shiitake. They also have a shrimp one which I skipped because I Will Not Eat The Bugs.
Read 4 tweets
8 Jun
There is a 100.0% chance that is a Roman spear design, I don’t even need to look it up to know
Roughly 2 meters in length, wood shaft, topped by an iron tip about 20% of the total length- it’s a fucking hasta
Look at how messed up the grass he’s standing on is. I’ve seen driving ranges with better turf- you just know he’s out there for hours a day, practicing his technique
Read 4 tweets
28 May
YOU, CONTEMPTIBLE PEASANT: Screaming at each other in a Twitter Spaces about SPAC activism on a Friday night
ME, 300 IQ MIND SAMURAI: Preparing to eat a 12 course meal made entirely of different flavors of foam and gelatin
1. A pea sphere. Why a sphere? Who knows.
2. Smoked hamachi with what I can only describe as “other Japanese stuff”
3. Beet chips with caviar between them.
4. Foie gras. Cowardly sommeliers continue to refuse to pair this with sauternes for the normies, needed to special order
5. Bread. It’s bread, it’s good, c’mon.
6. Pheasant corn dog. Why would you use a low fat white meat to replace pork except to impress with novelty of having pheasant? Thumbs down.
7. Duck main- can’t get enough duck with red fruit.
8. FINALLY, the hibiscus foam arrives.
Read 4 tweets
24 May
lOnG vOl fOR thE NExT 1o0 YeArS
It is literally unbelievable to me that you can accurately forecast more or less the exact liquidation of XIV just months before it happens and be up less than 1.5% for the quarter. Deserves a trophy for the worst portfolio implementation of a trade idea in history
Let it be known that Chris has graciously responded to my questions about vehicle structure to a sufficient degree that I consider this beef "squashed". The fund is a small component of assets relative to SMA overlays, which are adjusted to fit the client and perform quite well.
Read 4 tweets
24 Apr
Alright, T+15 days since shot 2 and we’re doing indoor dining again. To start: a 2014 Egon Müller Scharzhofberger Spätlese
Clockwise from top: blistered shishito peppers, tuna inari pockets, grilled @macrocephalopod, hijiki seaweed salad, and sea trout crudo.
Next: Tempura accoutrements, accompanied by tempura.
Read 5 tweets
19 Apr
Do NOT start an emerging manager under any circumstances. Do not work for a pre-launch manager without a nine figure seed investor, even if they offer you “equity”, even if they’re super smart, even if you’re getting a base pay raise from your last job. Just don’t do it.
Being an emerging manager is like doing a PhD because you want to be a tenure track professor. It is presented to you as the natural continuation of your path thus far, you have probably interacted only with success stories, and you absolutely, positively, Should. Not. Do. it.
Here is a checklist of conditions to be a EM:
1. Mom/Dad are worth over $10mm
2. You worked for GS/MS/etc
3. You worked for Citadel/etc
4. You personally know 5+ allocators willing to drop $25m+
5. You actually know how to manage a portfolio
That gets you to ~25% success chance
Read 5 tweets

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