Dr Greg Kelly Profile picture
Aug 1, 2021 18 tweets 5 min read Read on X
I think much of the incoherence & backflips in #COVID19 response, esp in rich countries, came about b/c ppl don't understand who ICU teams are & what they do

I'm an intensive care specialist who did an MBA to try & understand this better myself, here goes at an explanation: 🧵⬇️
Firstly, it's TOTALLY MEANINGLESS to talk about death or mortality rates in a pandemic without talking about ICU teams

If you are in a rich country with a functioning health system there is ALWAYS an ICU team standing between you & a potentially avoidable premature death
We're NOT used to thinking like this b/c epidemiologists & ID normally think either about outbreaks of deadly diseases in places w/out ICU teams Ebola in Africa) OR non deadly diseases in other places where ICU is irrelevant - gonorrhoea is embarrassing, not life threatening
The other outbreaks we've had in the era of modern ICU teams (SARS, MERS, etc) have severely strained local systems but not overwhelmed them - hence ICU capacity didn't become a major issue
ICU as a field was developed because of another pandemic of avoidable premature death: polio

Kids dying b/c they couldn't breathe, realisation that if we helped them breathe they wouldn't die

So ICU is inextricably linked to pandemics, we just forgot

nature.com/articles/d4158…
As well as never thinking about how pandemics meet ICU capacity in the modern era few people understand what ICU teams actually does in a modern system

ICU is the CENTRE OF GRAVITY of high intensity, hospital health care

Primary care other centre of gravity, of community care
ICU is not one thing - like cancer care, or heart surgery, transplant, etc

Rather, ICU teams look after the sickest patients at their most vulnerable time FROM EVERY OTHER AREA

ALL high intensity health care DEPENDS ON ICU TO FUNCTION
B/c workload of ICU teams drawn from diverse areas the patients average out & DEMAND IS RELATIVELY STABLE

Liver transplant work is up, neurointerventional slightly down - etc

Capacity so finely tuned that ONE PATIENT can strain system
Which patients strain system? Those that stay long time. Big majority ICU patients come in & get better quickly.

E.g. 85% of our pts are in & out < 3 days. Remaining 15% take weeks or even months

Those 15% of our 'long stay' patients = 2/3 of our bed capacity
Why is this so relevant for #COVID19? If you make it to ICU with COVID, esp. if you end up on a ventilator YOU STAY A VERY LONG TIME

Melbourne data last year - median ICU LOS 16 days. UK data avg 30 days

So just 1 severe COVID pt = estimated 20 heart or major cancer surgeries
So those 50+ patients we have in NSW, many on ventilators, represent far more workload than an average 50 ICU patients. It's not just that it's 6% of our 875 beds, it represents FAR MORE OF OUR BED DAYS
Remember the finely tuned capacity? Yep, well those 50 don't come with reduction in anything else

The pandemic patients are always 'on top' of everything else. In fact, this year, it's on top of worse seasons of seasonal viruses, plus all the elective work we are catching up on
Can we just expand the ICU teams? My mate has a 3D printer & said he can make a ventilator

It took me 15 years to train & I can't really work any harder so that's not easy thing to do. ALL OF OUR STAFF are specialists - nurses, physios, pharmacists, social work, child life, etc
Sure we can surge ICU team capacity temporarily but it is NOT SUSTAINABLE

UK NHS already seeing effect with staff leaving rather than face another surge. Costs of sick leave, mental health, lack of training, no time to build systems. Robbing Peter to pay Paul
This is why western countries, despite repeated flirtations with #LiveWithCovid repeatedly find they can't

Because you can't die prematurely in rich country w/out meeting ICU team

& if ICU overwhelmed w #COVID19 (remember happens v easily) then we CAN'T DO ALL THE OTHER STUFF
This means we need #COVIDZero to AVOID THE ROLLERCOASTER that almost every country's graphs have

Then, in order to open safely need:
1. High vax rate (probably including kids once safe & approved vax available)
2. #COVIDisAirborne recognition & mitigation
3. Test Trace Isolate
Truth of this is demonstrated by the few countries w advanced health systems that had national experience w deadly epidemics in modern era (e.g Taiwan, Singapore w SARS)

They have NOT F#*CKED AROUND a la "live with covid"

Understand that #COVIDzero is the only coherent response
Great piece here from @EJBourke that explores these issues in beautiful and human detail

abc.net.au/radio/adelaide…

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More from @drgregkelly

Dec 6, 2022
“Immunity debt as an individual concept is not recognised in immunology”

A timely, elegant & well researched article that addresses an important piece of contemporary misinformation - so called 'immunity debt'

Quotes from article🧵

#SARSCoV2

ft.com/content/064000…
"The discussion swirling around immunity debt shows how easy it is for a plausible-sounding theory to circulate as misinformation"
"In this case, misinformation risks promoting the unfounded assertion that infections are clinically beneficial to children, as well as feeding the revisionist narrative that Covid measures did more harm than good."
Read 7 tweets
Sep 15, 2022
Via Prof Peter Doherty, Nobel laureate for his fundamental work on viruses and immunology

His explanation in a lecture last year that the reason #COVID19 can be so harmful is b/c it can enter almost every cell in the body, unlike most other viruses, was a lightbulb moment for me
For those interested, here is an article about the ACE2 receptor, which is what the covid spike protein uses to bind to & gain entry to the cell. It’s almost everywhere we’ve looked in the body which goes some way to explaining COVID’s many manifestations

frontiersin.org/articles/10.33… Image
And here is the Professor’s delightfully straightforward video from last year. This guy is a giant of immunology and I love how clearly he can communicate big ideas.
Read 4 tweets
Sep 4, 2022
My prediction on #COVID19 having been a doctor for almost 20 yrs & been deeply involved in the pandemic:

It will end, eventually, through slow adoption of NPIs + mucosal vax. BUT, if you have bad #longcovid by then we prob WON'T HAVE CURE in your lifetime. So avoid until then
What does that mean?
- Get #COVID19 as few times as possible (none is best)
- Get lowest dose of virus if you do get it (masks, safe indoor air)
- Be as vaccinated as possible
- Recover properly

I believe that we will have treatments for #longcovid but not a total, one-off cure
What those NPIs are, I think will depend on where you are. In Asia masks likely to have an ongoing role. In the West it looks increasingly like the NPIs will mostly be indoor air quality measures (better ventilation and HEPA).
Read 5 tweets
Aug 23, 2022
Important clarification re. repeat #COVID19 infections

No doubt a repeat infection is worse than no repeat infection - EVERY time carries risk of bad outcome.

What is still debated is whether an infection makes bad outcome from future infection more or less likely. Brief🧵
The fact the second point is being debated should not distract you from the first. Even if you've been infected one or more times you should try to protect yourself from another.
Earlier, some thought 1 infection=absolute long term protection. Definitely wrong

Science not settled on whether 1 infection provides degree of overall protection or is in fact harmful, which there is increasing evidence to support

Key: protect yourself from next infection
Read 7 tweets
Aug 15, 2022
The 5 Fs of getting effective masks on the faces of your loved ones for #COVID19 protection in the real world

1 - Filtration
2 - Fit
3 - Feel
4 - Fashion
5 - Finances
1, Filtration

Refers to the % of potential covid containing particles (i.e aerosols) the mask material filters out. Cloth & surgical masks are unrated, untested & unpredictable but let’s be generous & say they filter 50%
But…because cloth and surgical masks are not designed or tested to filter reliably these numbers are highly variable - a well fitted surgical mask might be 80%, a poorly fitted cloth one 10%. There’s no real way to know
Read 17 tweets
Jul 2, 2022
This should be a proper “oops” moment in our #COVID19 response, and quite possibly an “oh shit” one

Here is real world data confirming earlier predictions that the time between covid waves would progressively decrease

Why is this so concerning? 🧵
Briefly, waves grow when each infected person infects average > 1 person & end when each infects < 1 bc people got infected & either develop some immunity to that variant, die,or behaviour changes

Vax contribute to baseline immunity (that’s good) but prob too slow to affect wave
A new wave occurs when a new variant that is different enough from previous appears - which means that the average immunity is low enough (plus behaviour permits) each infected person to infect on average > 1 person, that wave ends as above
Read 8 tweets

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