Mammary tumorigenesis [in mice] was very sensitive to linoleate [seed oils' main component] intake and increased proportionately in the range of 0.5 to 4.4% of dietary linoleate. cancerres.aacrjournals.org/content/45/5/1…
Most Americans consume enough seed oils that they're above a plateau in cancer causation. In other words, they're exposed to the maximum cancer-promoting amount.
This may be why associational studies are inconclusive: almost no one consumes a low level of linoleic acid
"Linoleic acid (LA), an essential n-6 polyunsaturated fatty acid (PUFA), was identified as an agent in dietary fat that is responsible for an up-regulation of tumor growth in vivo." pubmed.ncbi.nlm.nih.gov/17418560/
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Dr. Roy Taylor, who has done groundbreaking work in diabetes reversal, and colleagues explain how type 2 diabetes can be reversed by weight loss and avoidance of weight regain
Alcoholic liver injury is mediated by PAI-1, a blood clotting factor.
Linoleic acid, main fraction of seed oils, also increases PAI-1; this shows that seed oils might be doing the same thing to the liver as heavy drinking.
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