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Anthony J Leonardi, PhD, MS Profile picture
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3 Aug, 4 tweets, 2 min read
SARS-Cov-2 should not be regarded as a childhood disease you "build up" immunity to

There will be no competent durable immunity via infection in the general populace; long-lived cells in the marrow is not good enough

Again, it's neurotropic with a SAG. Do not infect 4 immunity
The genetic programmes responsible for immune evasion are deeply concerning. I have said for a long time this virus beats adaptive memory.

We now scramble for antivirals.

The trajectory is for more chronic infection
Gene invention for what may be the purpose of further immune evasion.

We are training it against innate immunity by infecting the youth (more reason why Bossche is foolish)

People keep asking what sag means. SAG means superantigen. It is a piece of protein that activated t cells nonspecifically. those t cells harm adjacent tissues like the brain.
jstor.org/stable/24939021

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More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
14 Jul
Delta has changed the game. I used to think a 70% community vaccination level would be sufficient to protect children in schools without their vaccination

Onward transmission of Delta among vaccinated in Israel caused infection of the youth. nature.com/articles/d4158…
Therefore, these calculations and practices must be reassessed. Reasonably, Israel is moving to vaccinate their youth. Ignoring this changed metric comes at the cost of more confusion. reuters.com/world/middle-e…
So:
1) via breakthrough, Delta has upset the argument youth are protected by adult vaccination
2) Onward transmission is indubitably more frequent
3) Physiological consequences of breakthrough infection by Delta have yet to be assessed.
washingtonpost.com/opinions/2021/…
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
4 Jul
In cases where people have been vaccinated and then had a breakthrough case and developed anosmia-

Do they have autoantibodies to neurological proteins or brain T cell infiltrates or hippocampal changes like in the UK Biobank study? upi.com/Health_News/20…
2/ These studies correlate and illustrate the brain changes from Covid-19. This study showed smaller areas in gustatory and memory regions of the brain of people after Covid. medrxiv.org/content/10.110…
3/ sadly, these changes were seen even in mild cases. Another study out of Stanford showed that T cells infiltrate the brain in Covid-19. Worrisome- this can cause encephalitis and brain damage. nature.com/articles/s4158…
Read 7 tweets
Anthony J Leonardi, PhD, MS Profile picture
26 Jun
This warrants concern and more investigation

SARS Cov 2 RNA and Spike protein is being detected in monocytes up to 15 months after infection in a sizeable proportion of patients.

biorxiv.org/content/10.110…
This corroborates a study at Yale that also detected RNA in monocytes in the acute setting. biorxiv.org/content/10.110…

It's possible these monocytes are trafficking to the brain, and bringing inflammation with it.
Monocytes can potentiate and beget brain inflammation.

Following infection, there is a swath of neuropsychiatric issues with cov2 AND T cells in the brain
frontiersin.org/articles/10.33…
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
22 Jun
Cov2 is NOT comparable to flu

Don't ever listen to those comparing Cov2 to influenza.

In *terminal* cases of Influenza, there were no T cells in the brain.

In Cov2, *all* but 1 patient in this paper had T cells in the brain. ImageImageImageImage
From this paper. nature.com/articles/s4158…
Why did people wait for harm to emerge instead of looking at the mechanisms?
Read 6 tweets
Anthony J Leonardi, PhD, MS Profile picture
17 Jun
If you leave critical decisions up to charlatans and people that overextend their expertise you end up with repeat waves and reinfections like in India when challenged with new variants.

Infected should have a boost with mrna for variant protection.
studies come out all the time showing this. Only herd immunity apologists who called it wrong and the recklessly ignorant will maintain infection confers better protection.
In regard to the cleveland clinic preprint: Charlatans that cannot contextualize a study with its environment by grasping temporal shifts in context (aka a delta, P1, or b1351 driven encroaching wave) should not be allowed near policy.
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
16 Jun
This is concerning.

When controlling for age, body habitus, and other variables, people who had covid had sizes of key brain structures 4 standard deviations below average.

The hippocampal gyrus is responsible for memory, in part.
medrxiv.org/content/10.110… ImageImage
These changes were not found to be different whether one was hospitalized or not.

The one metric where size increased post covid- ventricle volume- is a good marker for loss of brain matter. This usually increases with age. ImageImage
And before people tell you this was unexpected- no. This was predictable. Furin cleavage sites confer neurotropism and this was my primary concern with the virus. With the knowledge it had a Sag, the situation appeared more dire. Downplayers are culpable. Image
Read 5 tweets

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