Share this page!

Anthony J Leonardi, PhD, MS Profile picture
Twitter logo
26 Jun, 5 tweets, 2 min read
This warrants concern and more investigation

SARS Cov 2 RNA and Spike protein is being detected in monocytes up to 15 months after infection in a sizeable proportion of patients.

biorxiv.org/content/10.110…
This corroborates a study at Yale that also detected RNA in monocytes in the acute setting. biorxiv.org/content/10.110…

It's possible these monocytes are trafficking to the brain, and bringing inflammation with it.
Monocytes can potentiate and beget brain inflammation.

Following infection, there is a swath of neuropsychiatric issues with cov2 AND T cells in the brain
frontiersin.org/articles/10.33…
Remember, Cov2 is way more than the flu. Not even lethal flu brings T cells to the brain.

The neurotropism of the virus and the superantigen work together to make serious neuropathology.
I've noticed something. Many "experts" that minimize cov2 do not have immunology backgrounds-

The most I have seen is a Master's in immunology in one such minimizer, and it made a horrible case of Dunning-Kruger.

It's too bad neuro/immuno evidence of harm is slow to accumulate

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Anthony J Leonardi, PhD, MS

Anthony J Leonardi, PhD, MS Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
22 Jun
Cov2 is NOT comparable to flu

Don't ever listen to those comparing Cov2 to influenza.

In *terminal* cases of Influenza, there were no T cells in the brain.

In Cov2, *all* but 1 patient in this paper had T cells in the brain. ImageImageImageImage
From this paper. nature.com/articles/s4158…
Why did people wait for harm to emerge instead of looking at the mechanisms?
Read 6 tweets
Anthony J Leonardi, PhD, MS Profile picture
17 Jun
If you leave critical decisions up to charlatans and people that overextend their expertise you end up with repeat waves and reinfections like in India when challenged with new variants.

Infected should have a boost with mrna for variant protection.
studies come out all the time showing this. Only herd immunity apologists who called it wrong and the recklessly ignorant will maintain infection confers better protection.
In regard to the cleveland clinic preprint: Charlatans that cannot contextualize a study with its environment by grasping temporal shifts in context (aka a delta, P1, or b1351 driven encroaching wave) should not be allowed near policy.
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
16 Jun
This is concerning.

When controlling for age, body habitus, and other variables, people who had covid had sizes of key brain structures 4 standard deviations below average.

The hippocampal gyrus is responsible for memory, in part.
medrxiv.org/content/10.110… ImageImage
These changes were not found to be different whether one was hospitalized or not.

The one metric where size increased post covid- ventricle volume- is a good marker for loss of brain matter. This usually increases with age. ImageImage
And before people tell you this was unexpected- no. This was predictable. Furin cleavage sites confer neurotropism and this was my primary concern with the virus. With the knowledge it had a Sag, the situation appeared more dire. Downplayers are culpable. Image
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
23 May
Kids need to be vaccinated. Why?

Because things can go horribly wrong with infection, and infection is a process with proof of continuation.

Let's look at a few coronavirus examples and how they relate to cov2 🧵
Feline Infectious Peritonitis has a Furin Cleavage Site *EQUIVALENT* to Cov2

Fip in cats is notably a fatal, incurable, chronic illness, which interestingly requires a form/precursor of remdesivir to cure.

This must be given for 100 days.
So the cats bodies mount a response to the virus, but it is able to hide out and mutate in some, and cause vasculitis and neuroinflammation.

Sound familiar? vet.cornell.edu/departments-ce…
Read 9 tweets
Anthony J Leonardi, PhD, MS Profile picture
23 May
People seem to equate lockdowns with a 0 covid tolerance approach

I recall lockdowns are used in a "herd immunity" approach just before hospitals are overwhelmed.

In fact, "herd immunity" pursuant countries have arguably spent the most time in lockdown
The pursuit of herd immunity is probably why schools are used by some countries for a populational "natural" immunity

Infected children are less frequently hospitalized (1%). However, they are also less likely to seroconvert

Children do, however, infect young parents
In fact, you can see this pattern of children infecting parents from schools.

This could be why there are right-wing lobby groups for no masking.

They want to achieve an infection-based immunity period all the more quickly.
Read 9 tweets
Anthony J Leonardi, PhD, MS Profile picture
11 May
This is important:

B.1.617 has mutations that may *enhance* pathogenesis

A mutation at P681R in combination with L452R and E484Q significantly increases syncitia formation

This is when the cells fuse together, and it's linked to fatal disease.
2/ The Gupta lab found the mutations L452R/E484Q/P681R together significantly increase Syncitia formation.

This is a function of the polybasic cleavage site. Syncitia formation is linked to fatal diseasehttps://www.biorxiv.org/content/10.1101/2021.05.08.443253v1
3/ Syncitia are a way the virus kills T cells

This paper in Cell Death and Differentiation discusses how Syncitia internalize T cells in order to kill them

nature.com/articles/s4141…
Read 7 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

Like this author's thread?

Get emails when @fitterhappierAJ has new unrolls!

Check out other threads from @fitterhappierAJ!

Read all threads by @fitterhappierAJ

:(