Long-term NAC treatment attenuated flu-like symptoms. 2 x 600 mg NAC per day for 6 months, most subjects >65 years old.

25% of those taking NAC reported symptoms vs 79% of placebo.
N-acetylcysteine is cheap and is, for now, OTC, though the FDA is trying to restrict it. Amazon has removed NAC for example.
Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

Main mechanism of NAC is restoration of glutathione.

pubs.acs.org/doi/abs/10.102…

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More from @Mangan150

4 Aug
Berberine prevents atherosclerosis in animals through improved gut barrier function and reduced inflammation.

This tweet is not about berberine.
Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease

But, they told us it was all about cholesterol

pubmed.ncbi.nlm.nih.gov/32986965/
Read 4 tweets
1 Aug
Seed oils and cancer

High intake of omega-6 PUFAs is implicated in cancer of the breast, colon and, possibly, prostate

Omega-3 PUFAs and monounsaturated fatty acids such as oleic acid (omega-9) are protective.

pubmed.ncbi.nlm.nih.gov/10590211/
Mammary tumorigenesis [in mice] was very sensitive to linoleate [seed oils' main component] intake and increased proportionately in the range of 0.5 to 4.4% of dietary linoleate.
cancerres.aacrjournals.org/content/45/5/1…
Most Americans consume enough seed oils that they're above a plateau in cancer causation. In other words, they're exposed to the maximum cancer-promoting amount.

This may be why associational studies are inconclusive: almost no one consumes a low level of linoleic acid
Read 4 tweets
28 Jul
Seed oils (aka vegetable oils) and atherosclerosis leading to coronary heart disease

How could that work?

Let's take a look 👇
Oxidized LDL cholesterol is thought to play a critical role in formation of arterial plaques

Macrophages (white blood cells in the blood vessel wall) sense oxLDL, engulf it, leading to plaque formation

hindawi.com/journals/omcl/…
The oxidized fatty acid in oxLDL is mainly linoleic acid, the main component of seed oils

sciencedirect.com/science/articl…
Read 8 tweets
26 Jul
Niacin reduced mortality by 14% in men with metabolic syndrome.

That's great, but results would be far better if they got rid of metabolic syndrome.

Eliminating sugar, seed oils, and grains, and adding resistance training.
pubmed.ncbi.nlm.nih.gov/16461040/
Metabolic syndrome raises all-cause mortality rates by 50 to 100%

Crap food + sedentary lifestyle -> metabolic syndrome.

Around half of Americans age 50 and up have it.
ahajournals.org/doi/full/10.11…
No drug or natural product will be as affective as proper exercise and eliminating garbage food.
Read 4 tweets
18 Jul
Diabetics make up 40% of COVID deaths in US

If this is true, the implications are staggering.

If most of these are type 2 diabetics, most Covid deaths were in people with an entirely preventable/reversible disease.

nypost.com/2021/07/16/dia…
Dr. Roy Taylor, who has done groundbreaking work in diabetes reversal, and colleagues explain how type 2 diabetes can be reversed by weight loss and avoidance of weight regain

bmj.com/content/374/bm…
Low-carbohydrate diets should be the first-line treatment for diabetes, according to doctors who are leaders in this field

Type 2 diabetes shouldn't even exist.

sciencedirect.com/science/articl… Image
Read 7 tweets
13 Jul
Alcoholic liver injury is mediated by PAI-1, a blood clotting factor.

Linoleic acid, main fraction of seed oils, also increases PAI-1; this shows that seed oils might be doing the same thing to the liver as heavy drinking.

sciencedirect.com/science/articl…

ncbi.nlm.nih.gov/pmc/articles/P…
Non-alcoholic fatty liver disease patients had higher fructose intake and higher PAI-1.

Sugar raises PAI-1 via endotoxin -> fatty liver

academic.oup.com/jn/article/138…
Plasminogen Activator Inhibitor-1 (PAI-1): A Key Factor Linking Fibrinolysis and Age-Related Subclinical and Clinical Conditions

Central role played by PAI-1 in inflammation, atherosclerosis, insulin resistance and obesity

onlinelibrary.wiley.com/doi/full/10.11…
Read 4 tweets

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