Vipin M. Vashishtha Profile picture
Aug 5, 2021 8 tweets 6 min read Read on X
#Moderna says its vaccine shows durable 93% efficacy through 6 months.

Final analysis (median follow-up 5.3 mo):

-Against COVID19: 93.2%
-Against severe COVID19: 98.2%
-Against death: 100%

(Note: All data prior delta) 1/
Further break down of #Moderna efficacy by 2-month segments post 2nd dose; at month 4+, efficacy is 92.4%

#Pfizer vax (by months 4-6) efficacy is 84% - though against severe disease maintains 97%. 2/
Yet it expects antibody levels will start to wane, and with #delta there will be an increase in #breakthrough infections in fully vaccinated; it sees need for #boosters 3/
#Moderna says lab studies show a booster with half the dose of its #covid19 vaccine increases antibody levels against #delta by 42-fold. 4
#Moderna reports top-line findings from phase 2 study of #booster shot, noting neutralizing antibody titers had waned significantly by 6 months; Safety profile of dose 3 was similar to that of dose 2. 5/
The @WHO yesterday called for a moratorium on #boosters until September to enable countries that haven't had vaccine access to be able to administer first shots. 6/

But all these data are prior #Delta. So, we should take these results with a pinch of salt.

Probably, they're expecting a sharper drop in VE when the full effects of Delta are reflected in the coming months 7/

investors.modernatx.com/news-releases/…
Few countries have already decided to give a booster of Covid vaccines………Israel, France & Germany. 8/

forexlive.com/news/!/frances…

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More from @vipintukur

Jul 25
Researchers have discovered that gut bacteria produce a molecule that not only induces but also causes atherosclerosis, the accumulation of fat and cholesterol in the arteries that can lead to heart attacks and strokes.

This unexpected link between microbes and cardiovascular disease — the leading cause of death in humanity — is a paradigm shift. 1/Image
The new results show that some gut bacteria, in certain states, produce imidazole propionate, a simple molecule with six carbon atoms, eight hydrogen atoms, two nitrogen atoms, and two oxygen atoms (C₆H₈N₂O₂). This compound enters the blood, interacts with immature white blood cells, and triggers an inflammatory reaction in the arteries, which promotes the buildup of fatty plaques. Imidazole propionate induces atherosclerosis on its own. There’s a causal relationship. 2/Image
Furthermore, scientists observed elevated levels of imidazole propionate in one out of every five volunteers with active atherosclerosis, the type in which fatty plaques are more likely to rupture and form the blood clots that cause heart attacks and strokes. The new results demonstrate that atherosclerosis is not only a disease caused by fat, but that it also has an inflammatory and autoimmune component. 3/Image
Read 4 tweets
Jul 20
An exceptional study from Stanford found that lymphocytes from ME/CFS & #LongCOVID patients show elevated oxidative stress, disrupted redox balance, and mitochondrial damage.

These abnormalities lead to excess energy use by immune cells, which may contribute to severe fatigue and other symptoms. 1/Image
The researchers identified increased lipid peroxidation and glutathione metabolism changes, indicating shared metabolic dysfunction in ME/CFS and LongCOVID.

Females show higher mitochondrial ROS levels and insufficient antioxidant levels (GSH), while males show mitochondrial lipid oxidative damage. These findings suggest that the pathophysiology for ME/CFS and LC are distinct between sexes. 2/Image
The group also tested ROS-targeting therapies. Metforminshowed some benefit on CD4 T cell proliferation in vitro, and the findings suggest oxidative stress could be a target for diagnosis and therapy. 3/ Image
Read 4 tweets
Jul 19
New gene discovery may change cancer and autoimmune treatment!

Researchers have identified the #SDR42E1 gene as crucial for absorbing vitamin D from the gut and metabolizing it into the active hormone calcitriol, which is essential for bone health, immune function, and cellular processes.

They used CRISPR/Cas9 gene editing to disable SDR42E1 in HCT116 colorectal cancer cells, resulting in a dramatic 53% reduction in cancer cell viability while leaving healthy cells unharmed. 1/Image
The gene disruption triggered widespread molecular changes affecting over 4,600 downstream genes involved in sterol metabolism and cancer-related signaling pathways.

A specific mutation in #SDR42E1 on chromosome 16 has been linked to vitamin D deficiency, causing the protein to be cut short and rendered inactive. 2/Image
This discovery opens potential new avenues for precision medicine, including targeted cancer therapies and treatments for autoimmune diseases where vitamin D plays a regulatory role. 3/ Image
Read 5 tweets
Jul 18
A promising new COVID-19 vaccine candidate developed by researchers at the Centenary Institute and the University of Sydney has shown strong potential to protect against both current and emerging coronavirus variants.

By targeting features shared by a range of coronaviruses, the vaccine is designed to offer broader and longer-lasting protection as the virus continues to evolve. 1/Image
The new study shows that the vaccine candidate, named #CoVEXS5, protected mice from multiple coronaviruses, including the highly immune-evasive omicron XBB.1.5 variant and SARS-CoV-1, a relative of SARS-CoV-2 that was responsible for the 2002–2004 SARS outbreak. 2/ Image
In laboratory tests, CoVEXS5 reduced virus levels in the lungs of infected mice by approximately 99.9% compared to unvaccinated controls, demonstrating a dramatic protective effect. 3/ Image
Read 5 tweets
Jul 16
A new Yale study has found a promising target for treating the brain fog that can follow COVID-19 and offers new insight into a hypothesis about the origin of Alzheimer's disease.

Researchers obtained viable postmortem human retinal tissue and generated human retinal organoids that contain electrophysiologically active neurons.

They demonstrated that SARS-CoV-2 induced amyloid-β extracellular protein aggregates in human retinal explants and retinal organoids. 1/Image
While the etiology of Alzheimer’s disease remains unknown, there is growing support for the amyloid-β antimicrobial hypothesis.

Amyloid-β, the main component of amyloid plaques in Alzheimer’s disease, has been shown to be generated in the presence of microbes.

Entrapment of microbes by aggregated amyloid-β may serve as an innate immune response to pathogenic infections. 2/Image
Lastly, pharmacological inhibition of neuropilin-1 resulted in reduced amyloid-β deposition in human retinal explants treated with SARS-CoV-2 Spike 1 protein.

These results suggest that Spike 1 protein, during infection with SARS-CoV-2, can induce amyloid-β aggregation, which may be associated with the neurological symptoms experienced in COVID-19. 3/Image
Read 6 tweets
Jul 14
A new study reviewed skeletal muscle adaptations & post-exertional malaise in #LongCOVID. People with LongCOVID show reduced skeletal muscle oxidative capacity, smaller muscle fibers & increased glycolytic activity, all which may explain fatigue & post-exertional malaise. 1/ Image
Muscle biopsies revealed structural and metabolic changes similar to deconditioning, but also showed unique inflammatory and mitochondrial signatures, suggesting Long COVID involves distinct muscle pathology beyond simple inactivity. 2/ Image
Most research on long COVID has focused on immune function, but skeletal muscle adaptations in these patients are gaining more attention. There is clear evidence of skeletal muscle alterations, including mitochondrial and endothelial abnormalities in patients with long COVID that may underly whole-body exercise responses. 3/Image
Read 4 tweets

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