More details on the Guinea Marburg case from @WHO:
The man had symptoms from July 25, attended a small health favility on August 1 and died the next day in hos community.
Four high risk contacts are without symptoms. Further contact tracing is going on
Some context on Marburg:
Case fatality rate of 24 - 90 %
No specific therapeutics available
“In the early course of the disease, clinical diagnosis of MVD is difficult to distinguish from other tropical febrile illnesses, because of the similarities in the clinical symptoms”
This is the first Marburg case in Guinea
The village is “in a remote forested area located near the border with Sierra Leone and Liberia”
Guinea “has a fragile healthcare system which is further exacerbated by multiple disease outbreaks, recurrent epidemics” and COVID-19
This suggests “a high risk at the national level, requiring an immediate and coordinated response with support from international partners”
Risk for region: high, given close connections with Liberia and Sierra Leone
“risk associated with the event at the global level is low”
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WHO presser starts with @DrTedros talking about Marburg case in Guinea.
"About 150 contacts have been identified and are being followed up, including three family members, and the health worker who have been identified as high risk close contacts”, he says.
@DrTedros "There is no licensed vaccine for Marburg, although there are vaccines under development”, says @DrTedros.
“@WHO is working with our partners to seek opportunities to assess them during this outbreak through the R&D Blueprint for Epidemics"
@DrTedros@WHO "Last week, the 200 millionth case of #COVID19 was reported to @WHO just six months after the world passed 100 million reported cases”, says @DrTedros.
“And we know that the real number of cases is much higher."
Last week I wrote about some good news: The WHO‘s global trial looking for #covid19 drugs has restarted, now named SolidarityPlus.
Expect some more details in the @WHO presser that’s about to start, but here’s an overview of the drug candidates:
@WHO 1. imatinib
What?
cancer drug given orally
Why?
thought to protect epithelium lining the alveoli, where oxygen crosses from the lungs into the blood
Dutch trial in 400 hospitalized #COVID19 patients saw lower mortality, but not statistically significant thelancet.com/journals/lanre…
(presser starting in Geneva, back to this after that)
Last week I wrote a thread on Prussian Blue including a quote from Fontane’s Frau Jenny Treibel:
“What are all the cornflowers in the world compared with a Prussian blue factory?”
So it seems only fair to talk about the blue of the cornflower today... #TuesdayisBluesday
Blue flowers are beautiful but they are also quite rare.
Gardeners and naturalists had long noticed that a true blue seemed less common in flowers than a vibrant red or yellow. Goethe mentioned this in his “Theory of Colors” published in 1810, for instance:
This fascinated artists.
In German romanticism the blue flower became a symbol of longing, of the unattainable.
Joseph von Eichendorff wrote:
“I seek the flower of blue
Seek yet never can find.
I dream that in its hue
My happiness is enshrined."
“While hundreds of millions of people are still waiting for their first dose, some rich countries are moving towards booster doses”, says @DrTedros at @WHO press conference on #covid19.
@DrTedros@WHO "I understand the concern of all governments to protect their people”, says @drtedros. “But we cannot and we should not accept countries that have already used most of the global supply of vaccines using even more of it while the world's most vulnerable people remain unprotected"
@DrTedros@WHO In late May @DrTedros called for vaccinating at least 10% of the population in all countries by the end of September.
"We are now more than halfway to that target date, but we're not on track”, says @drtedros.
People often ask me what I find so fascinating about blue and what it has to do with science, so here‘s a story about one particular blue from right here in Berlin: #TuesdayisBluesday
Around 1706 alchemists in Berlin accidentally discovered a new blue. Johann Jacob Diesbach was working in the lab of Johann Konrad Dippel trying to make a red pigment, carmine. But he used some potash contaminated with animal blood by Dippel and ended up with a blue pigment.
They quickly realized the blue was stable and easy to make and that meant it was worth a fortune. Because good blue pigments were rare. Ultramarine, for instance, was laboriously made from lapis lazuli (shipped most prominently from the Badakshan region) and incredibly expensive.
"Almost 4 million cases were reported to who last week”, says @DrTedros at @WHO presser on #covid19. “On current trends, we expect the total number of cases to pass 200 million within the next two weeks. And we know that is an underestimate.”
@DrTedros@WHO "On average, in five of @WHO’s six regions infections have increased by 80%, or nearly doubled over the past four weeks”, says @drtedros.
“In Africa deaths have increased by 80% over the same period. Much of this increase is being driven by the highly transmissible Delta variant"
@DrTedros@WHO "So far, four variants of concern have emerged and there will be more as long as the virus continues to spread”, says @drtedros
"The rise is also driven by increased social mixing and mobility. The inconsistent use of public health and social measures and inequitable vaccine use"