WHO presser starts with @drtedros talking about Marburg case in Guinea.
"About 150 contacts have been identified and are being followed up, including three family members, and the health worker who have been identified as high risk close contacts”, he says.
@DrTedros "There is no licensed vaccine for Marburg, although there are vaccines under development”, says @drtedros.
“@WHO is working with our partners to seek opportunities to assess them during this outbreak through the R&D Blueprint for Epidemics"
@DrTedros@WHO "Last week, the 200 millionth case of #COVID19 was reported to @WHO just six months after the world passed 100 million reported cases”, says @drtedros.
“And we know that the real number of cases is much higher."
@DrTedros@WHO “At the current trajectory we could pass 300 million reported cases early next year”, says @drtedros.
"But we can change that.
We are all in this together. But the world is not acting like it."
@DrTedros@WHO "In October, WHO reported results of the Solidarity Trial, which tested 4 treatments for #COVID19, involving almost 13,000 patients in 500 hospitals in 30 countries”, says @drtedros.
@DrTedros@WHO "We expect final results from that trial next month”, says @dtredros.
(This is because the remdesivir arm was continued alone after those first results to gather more data…)
@DrTedros@WHO “Today, we're pleased to announce the next phase in the Solidarity trial, called SolidarityPlus”, says @drtedros.
(Wrote about this new phase of the trial last week: sciencemag.org/news/2021/08/g…)
@DrTedros@WHO In Finland, 14 major hospitals have joined the trial” says @HSarkkinen, Finland’s health minister.
“On sixth of August, two Finnish university hospitals in Tampere and in Helsinki were the first hospitals globally to start to randomize patients to the SolidarityPlus trial”,
@DrTedros@WHO@HSarkkinen “Despite the frightening third wave, which is occurring now, and the lack in so many countries of accurate reporting and enough testing, the pandemic has not impacted Africa in the ways which were expected”, says @ProfessorSow, Mali’s principal investigator of SolidarityPlus.
@DrTedros@WHO@HSarkkinen@ProfessorSow “That is not to say that Africa is still not at risk. It very much is”, says @ProfessorSow.
“We risk losing many hard fought gains of the last decade through the decimation of essential health services and the economic impact."
@DrTedros@WHO@HSarkkinen@ProfessorSow “The first trial was an extraordinary achievement”, says Marco Medina, national principal investigator in Honduras.“Hundreds of investigators around the world were working globally to evaluate an effective treatment for this pandemic of #covid19."
@DrTedros@WHO@HSarkkinen@ProfessorSow Q about Iota variant.
“The prevalence of Iota in the United States, where much of the variant has been detected, is actually decreasing, and the variant delta is actually increasing”, says @mvankerkhove. “So the Delta variant seems to outcompete the Iota variant."
@DrTedros@WHO@HSarkkinen@ProfessorSow@mvankerkhove 52 countries are taking part in SolidarityPlus and half of them have all the regulatory and ethical approvals in place, though more things are needed says Marie-Pierre Preziosi. “We have at least 10 to 15 countries, for which the drugs have been shipped."
@DrTedros@WHO@HSarkkinen@ProfessorSow@mvankerkhove SolidarityPlus includes 16 more countries and nearly 200 more hospitals than original Solidarity trial, notes Ana Maria Henao Restrepo.
“We are hopeful that the recruitment rates will be higher, much higher than in the initial phase"
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Last week I wrote about some good news: The WHO‘s global trial looking for #covid19 drugs has restarted, now named SolidarityPlus.
Expect some more details in the @WHO presser that’s about to start, but here’s an overview of the drug candidates:
@WHO 1. imatinib
What?
cancer drug given orally
Why?
thought to protect epithelium lining the alveoli, where oxygen crosses from the lungs into the blood
Dutch trial in 400 hospitalized #COVID19 patients saw lower mortality, but not statistically significant thelancet.com/journals/lanre…
(presser starting in Geneva, back to this after that)
Last week I wrote a thread on Prussian Blue including a quote from Fontane’s Frau Jenny Treibel:
“What are all the cornflowers in the world compared with a Prussian blue factory?”
So it seems only fair to talk about the blue of the cornflower today... #TuesdayisBluesday
Blue flowers are beautiful but they are also quite rare.
Gardeners and naturalists had long noticed that a true blue seemed less common in flowers than a vibrant red or yellow. Goethe mentioned this in his “Theory of Colors” published in 1810, for instance:
This fascinated artists.
In German romanticism the blue flower became a symbol of longing, of the unattainable.
Joseph von Eichendorff wrote:
“I seek the flower of blue
Seek yet never can find.
I dream that in its hue
My happiness is enshrined."
More details on the Guinea Marburg case from @WHO:
The man had symptoms from July 25, attended a small health favility on August 1 and died the next day in hos community.
Four high risk contacts are without symptoms. Further contact tracing is going on
Some context on Marburg:
Case fatality rate of 24 - 90 %
No specific therapeutics available
“In the early course of the disease, clinical diagnosis of MVD is difficult to distinguish from other tropical febrile illnesses, because of the similarities in the clinical symptoms”
This is the first Marburg case in Guinea
The village is “in a remote forested area located near the border with Sierra Leone and Liberia”
Guinea “has a fragile healthcare system which is further exacerbated by multiple disease outbreaks, recurrent epidemics” and COVID-19
“While hundreds of millions of people are still waiting for their first dose, some rich countries are moving towards booster doses”, says @DrTedros at @WHO press conference on #covid19.
@DrTedros@WHO "I understand the concern of all governments to protect their people”, says @drtedros. “But we cannot and we should not accept countries that have already used most of the global supply of vaccines using even more of it while the world's most vulnerable people remain unprotected"
@DrTedros@WHO In late May @DrTedros called for vaccinating at least 10% of the population in all countries by the end of September.
"We are now more than halfway to that target date, but we're not on track”, says @drtedros.
People often ask me what I find so fascinating about blue and what it has to do with science, so here‘s a story about one particular blue from right here in Berlin: #TuesdayisBluesday
Around 1706 alchemists in Berlin accidentally discovered a new blue. Johann Jacob Diesbach was working in the lab of Johann Konrad Dippel trying to make a red pigment, carmine. But he used some potash contaminated with animal blood by Dippel and ended up with a blue pigment.
They quickly realized the blue was stable and easy to make and that meant it was worth a fortune. Because good blue pigments were rare. Ultramarine, for instance, was laboriously made from lapis lazuli (shipped most prominently from the Badakshan region) and incredibly expensive.
"Almost 4 million cases were reported to who last week”, says @DrTedros at @WHO presser on #covid19. “On current trends, we expect the total number of cases to pass 200 million within the next two weeks. And we know that is an underestimate.”
@DrTedros@WHO "On average, in five of @WHO’s six regions infections have increased by 80%, or nearly doubled over the past four weeks”, says @drtedros.
“In Africa deaths have increased by 80% over the same period. Much of this increase is being driven by the highly transmissible Delta variant"
@DrTedros@WHO "So far, four variants of concern have emerged and there will be more as long as the virus continues to spread”, says @drtedros
"The rise is also driven by increased social mixing and mobility. The inconsistent use of public health and social measures and inequitable vaccine use"