@QiaochuYuan I kinda do
@QiaochuYuan More seriously I don’t think parents had warmer relationships with their kids, or husbands with wives, decades or centuries ago.

Friendships might have been easier to maintain in communitarian societies, but also often less intimate & more rote.
@QiaochuYuan And the omnipresence of busybodies horrifies me.

Read Rabbit, Run by John Updike. It captures the horror of small-town life where you have no privacy ever and you can’t do anything the neighbors disapprove of.
@QiaochuYuan As a woman and some-kind-of-not-neurotypical, being able to have friends I really connect with basically requires a.) the internet, and b.) the feminist concept that a woman can be alone nonsexually with a man.
@QiaochuYuan "Civilization is the process of setting man free from men", completely unironically.

The freedom to be *alone* and the freedom to *choose* your companions are two sides of the same coin, and you can only get that with "atomized" modernity.
@QiaochuYuan Atomized modernity: did you mean "young women can move to the city alone, earn their own money, and have sex with people not chosen by their fathers?"

This appliance means freedom. Image
@QiaochuYuan So does this appliance.

It means you can MOVE. Image
@QiaochuYuan This appliance means you have HEARD of the big city, women working, women marrying for love.

Children going to school and being taken to the doctor and being treated kindly by their parents.

Kirk and Uhura kissing.

TV's not all good, but there's some important good stuff. Image

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More from @s_r_constantin

15 Sep
Yikes!

I was rooting for them to succeed, but this report has some damning customer quotes about their machines not actually working.
It’s a very rhetorically aggressive report and makes some unfair arguments.

Saying that “just” miniaturizing assays and running them faster doesn’t make a difference is ignorant. Moore’s Law is “just” making smaller features and faster computer chips.
But unless the quotes from unhappy customers are fabricated, this is pretty unanimous disappointment in the machine’s price, accuracy, reliability, and usability from 14 major biotech/pharma companies.
Read 28 tweets
4 Aug
There’s a mode of social interaction that I really miss, and that’s “high volume/density, low expectations.”
Small talk is “low volume/density, low expectations”. You don’t expect much from it, but you also don’t spend much time or energy on it. Low information content, safe but not that fun.
An important work meeting is “low volume/density, high expectations.” You’re trying to keep it brief to respect everyone’s time. And there are high expectations that everything you say is civil, accurate, relevant, useful, non-obvious, etc.
Read 27 tweets
2 Aug
Suppose you find out that someone you like/respect secretly hates you.

What would make you MOST unhappy, if they hated you for a reason you agree is fair/reasonable from their position, or for a reason that you think is unfair/unreasonable on their part?
Suppose you find out someone you like/respect secretly hates you, for a good reason. How do you feel?
Suppose you find out someone you like/respect secretly hates you, for a bad or unfair reason. How do you feel?
Read 5 tweets
16 Jun
🧵:
One like = one piece of advice from Wine Mom Sarah to the youths

(Specific questions also welcome)
1: never invert a matrix if you don’t have to
2: when visiting colleges or interviewing for jobs, if it seems like the place is full of assholes, it probably is
Read 63 tweets
8 May
My current “impractical” project is building a comprehensive list of interventions that cause >20% complete tumor regression in metastatic solid tumors. Basically, the hardest of hard modes for cancer.
I don’t think I’m quite done (will put it up in a post when I’m satisfied), but here’s what I’m seeing so far.
1. There are some things I don’t expect to generalize much. Stereotactic radiation for lung metastases & intratumoral injections of Nasty Stuff for skin metastases — great where available but you can’t always access the tumors.
Read 49 tweets
5 May
endpts.com/focused-on-the… One of many companies trying to make cell therapy more efficient.
Cell therapy means taking cells out of a patient or donor, genetically modifying them, and putting them back in to treat a disease. CAR-T therapy does this with immune cells and has remarkable results in some cancers. But it costs $100k to produce one dose.
The potential patient population is huge; the world’s production capacity is tiny.

You effectively have to produce a custom “drug” in the hospital, for each patient.
Read 13 tweets

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