Rx: doxycycline / azithromycin / ceftriaxone / IV PCN
Jarisch–Herxheimer reaction: abrupt onset of F/C, HA, tachycardia, hyperventilation, flushing, and hypotension 1–2h after Rx with penicillin or other antimicrobial agents
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2/ #MayoIDQ
46F with uncontrolled DM and recent DKA is admitted because of left sided HA for a month. PE: orbital apex syndrome. Head imaging shown. ENT/neurosurgery proceeded with debridement. Pathology shown. Which one of the following choices is most correct?
3/ Case diagnosis: Rhinocerebral #mucormycosis due to #Rhizopus in a person with poorly controlled diabetes mellitus
A 68 year old man presents with weight loss and dysphagia for 6 weeks. Upper endoscopy is shown. What is your diagnosis? #MayoIDQ and case details to follow
2/ 68M. No PMH. 6w gradual dysphagia to solids with 20 lb weight loss. No F/C/sweats. PE: cachexia. WBC 4.7 Cr 0.9 CXR normal. HBV(-). Rx fluconazole.
Per your suggestion: HIV VL 56K CD4 26. Patient willing to start ART immediately. Genotype pending. You suggest which one?
3/ Case diagnosis: Esophageal candidiasis in a man with newly diagnosed AIDS
Suggested ART: TAF-FTC-bictegravir
ART consists of 2 NRTI in combo with 3rd drug: INSTI, NNRTI or boosted PI.
Among them: INSTI is preferred for various reasons (next)
2/ 39M. No PMH. HIV-. No IDU.
PE: jaundice, endophthalmitis, no dental issues, b/l rales, new systolic murmur, tender RUQ
WBC 18.3 Alk phos 250.
CT chest / abdomen (photo)
TEE: mitral valve vegetation
Which of the following is the most likely pathogen? #MayoIDQ
3/ Let us use this case to highlight clinical pearls about liver abscess:
Two major categories 1. Pyogenic liver abscess 2. Amoebic liver abscess
In this case, there are factors that favor pyogenic liver abscess: endocarditis, septic pulmonary emboli and endophthalmitis