Images of Infectious Diseases
46F with diabetes presents with orbital apex syndrome. Imaging and histopathology shown. What is your differential diagnosis? #MayoIDQ to follow @StephanieGrach @ZYetmar @omarabusaleh15
46F with diabetes presents with orbital apex syndrome. Imaging and histopathology shown. What is your differential diagnosis? #MayoIDQ to follow @StephanieGrach @ZYetmar @omarabusaleh15
2/ #MayoIDQ
46F with uncontrolled DM and recent DKA is admitted because of left sided HA for a month. PE: orbital apex syndrome. Head imaging shown. ENT/neurosurgery proceeded with debridement. Pathology shown. Which one of the following choices is most correct?
46F with uncontrolled DM and recent DKA is admitted because of left sided HA for a month. PE: orbital apex syndrome. Head imaging shown. ENT/neurosurgery proceeded with debridement. Pathology shown. Which one of the following choices is most correct?
3/
Case diagnosis: Rhinocerebral #mucormycosis due to #Rhizopus in a person with poorly controlled diabetes mellitus
Rx:
Surgical debridement
Liposomal #Amphotericin B
Later: transitioned to #Posaconazole upon clinical control and improvement
Case diagnosis: Rhinocerebral #mucormycosis due to #Rhizopus in a person with poorly controlled diabetes mellitus
Rx:
Surgical debridement
Liposomal #Amphotericin B
Later: transitioned to #Posaconazole upon clinical control and improvement
4/
#Mucormycosis
First-line treatment with high-dose liposomal #amphotericin B is strongly recommended.
IV #isavuconazole and IV or DR tablet #posaconazole are recommended with moderate strength. Both triazoles are strongly recommended as salvage Rx.
doi.org/10.1016/S1473-…
#Mucormycosis
First-line treatment with high-dose liposomal #amphotericin B is strongly recommended.
IV #isavuconazole and IV or DR tablet #posaconazole are recommended with moderate strength. Both triazoles are strongly recommended as salvage Rx.
doi.org/10.1016/S1473-…
5/
#Ibrexafungerp
This first-in-class #triterpenoid antifungal approved by FDA for Rx of vulvovaginal #candidiasis.
This oral "#fungerp" inhibits biosynthesis of β-(1,3)-D-glucan in the fungal cell wall (mechanism similar to echinocandins)
ncbi.nlm.nih.gov/pmc/articles/P…
#Ibrexafungerp
This first-in-class #triterpenoid antifungal approved by FDA for Rx of vulvovaginal #candidiasis.
This oral "#fungerp" inhibits biosynthesis of β-(1,3)-D-glucan in the fungal cell wall (mechanism similar to echinocandins)
ncbi.nlm.nih.gov/pmc/articles/P…
6/
#Rezafungin is a next-generation #echinocandin with pharmacokinetic advantages, including a prolonged half-life (~133 hours) and high plasma drug concentrations.
doi.org/10.1093/cid/ci…
#Rezafungin is a next-generation #echinocandin with pharmacokinetic advantages, including a prolonged half-life (~133 hours) and high plasma drug concentrations.
doi.org/10.1093/cid/ci…
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