Weekend Digest
Name the pathogen
5 Clues
Gram-positive bacillus.
Spore.
Food. Wound. Iatrogenic.
Drooping eyelids.
Preserved sensory function.
Name the pathogen
5 Clues
Gram-positive bacillus.
Spore.
Food. Wound. Iatrogenic.
Drooping eyelids.
Preserved sensory function.
2/
#Clostridium #botulinum
Spore-forming Gram-positive bacillus
Ubiquitous: vegetable, soil, seafood
Neurotoxin: A-H (A, B, E cause human disease)
Toxin binds to receptor in presynaptic terminal —> blocks neurotransmitter release (blocks cholinergic neuromuscular innervation)
#Clostridium #botulinum
Spore-forming Gram-positive bacillus
Ubiquitous: vegetable, soil, seafood
Neurotoxin: A-H (A, B, E cause human disease)
Toxin binds to receptor in presynaptic terminal —> blocks neurotransmitter release (blocks cholinergic neuromuscular innervation)
3/
#Botulism (epidemiologic clues)
1. Infant botulism (raw honey)
2. Foodborne (preformed toxin; home-canned fermented food)
3. Wound botulism (IDU/ black tar heroin)
4. Iatrogenic (cosmetic use)
5. Bioterrorism (mass poisoning)
#Botulism (epidemiologic clues)
1. Infant botulism (raw honey)
2. Foodborne (preformed toxin; home-canned fermented food)
3. Wound botulism (IDU/ black tar heroin)
4. Iatrogenic (cosmetic use)
5. Bioterrorism (mass poisoning)
4/
#Botulism is characterized by bilateral cranial neuropathies and symmetric, descending flaccid motor paralysis:
* Dysphagia
* Muscle weakness
* Diplopia
* Ptosis
* Blurry vision
* Slurred speech
* Respiratory distress
* Ocular palsy
Absence of sensory nerve dysfunction
#Botulism is characterized by bilateral cranial neuropathies and symmetric, descending flaccid motor paralysis:
* Dysphagia
* Muscle weakness
* Diplopia
* Ptosis
* Blurry vision
* Slurred speech
* Respiratory distress
* Ocular palsy
Absence of sensory nerve dysfunction
5/
Diagnosis: detect #botulinum toxin in serum, stool, food; culture botulinum-producing C. botulinum from stool, wound.
Rx:
Antitoxin (heptavalent antitoxin; botulinum IG)
Supportive care
Debride wound + PCN
Antibiotics NOT needed in food borne, intestinal and infant botulism
Diagnosis: detect #botulinum toxin in serum, stool, food; culture botulinum-producing C. botulinum from stool, wound.
Rx:
Antitoxin (heptavalent antitoxin; botulinum IG)
Supportive care
Debride wound + PCN
Antibiotics NOT needed in food borne, intestinal and infant botulism
6/
Bonus question: why is it named #botulinum?
Bonus question: why is it named #botulinum?
/7
Clostridium botulinum#
Sausage - botulus (Latin word)
Causes illness similar to the sausage poisoning in Germany during 1820s vs. bacteria is shaped like a sausage
antimicrobe.org/h04c.files/his…
Clostridium botulinum#
Sausage - botulus (Latin word)
Causes illness similar to the sausage poisoning in Germany during 1820s vs. bacteria is shaped like a sausage
antimicrobe.org/h04c.files/his…
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