I look at how the Proteasome works.
1/ The Proteasome is a cellular organelle. Its like the recycling bin for proteins. When a cell is done with a protein, it tags it for destruction in the process called ubiquitination.
2/ The proteasome will load these tagged proteins and break them down into peptides of about 7 to 10 amino acids in length for recycling. They will further be broken down after into single amino acids for reuse to build new proteins.
3/ The proteasome is made up of 3 subunits. The central 20s subunit is called the catalytic barrel. This is the business part of the proteasome where it actually breaks down the peptide chain of amino acids into smaller peptides.
4/ The top an bottom of the 20s subunit has a 19s subunit bound to each end. These are designed to recognize the poly ubiquitin tails on proteins and load them into the barrel for shredding.
5/ The 19s subunit will also be responsible for unfolding the proteins into a single long peptide chain so that it feeds smoothly into the catalytic barrel.
6/ Together the 3 subunits make up the full 26s proteasome structure. The 3 subunits are not always assembled in the cell. They only come together when they are directed to do so.

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More from @Biotech2k1

15 Sep
#Cancer_Immunology TME

A look into the Tumor Micro Environment (TME).
1/ There is a complex set of interactions that must go on between a tumor and its surroundings. It has to interact with the tissue cells, it needs nutrients, it needs oxygen, it needs to survive and proliferate in a hostile environment.
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My Game Plan:

$BPMC 3.37% core position
$MRTX 3.37% core position
$TPTX 3.37% core position
$SDGR 1.35%
$RVMD 2.7%
$RLAY 2.7%
$ERAS 0% considering but way too expensive
$RPTX 2.02%
$KNTE sold out as it was my weakest link
Protein Degraders:
$ARVN 1.35%
$KYMR 1.35% paying down a core position
$CCCC 2.02% paying down a core position
$GLUE 1.35% paying down a core position
CRISPR/Old Antibodies
$CRBU 1.35% paying down a core position
$BCAB 2.7% will sell out when I think its good opportunity.

CRISPR is way to crazy on values to waste money on here. It will implode someday, and I will be waiting.
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A look into protein degraders.
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15 Sep

A look at ubiquitination.
1/ Cells make, regulate and break down proteins constantly. They have a system to control the regulation of the proteins they produce. This is to remove unwanted proteins when no longer used.
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Looking at Protein Degraders:

Looking at the pathway coverage of the deragers.
1/ $ARVN
AR - Androgen receptor
ER - Estrogen receptor
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MYC - transcription factor
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