1/ There are 2 types of protein degraders in development and a 3rd in concept phase of development. The first is the monoDAC, the second is the biDAC and the last is the triDAC.
2/ The monoDAC will bind with a covalent chemical bonding to the E3 ligase and alter its targeted function. It changes the shape of the E3 and directs it to place the ubiquitin molecule onto a protein it directs.
3/ The monoDAC is typically smaller and has some advantages due to its size. It can also have more off target effects due to how it works. These are also referred to as mono valent or molecular glues. 
4/ The biDAC has 2 molecules that are held together by a linker. The first targets the desired E3 ligase and the other targets the desired protein. This bring together the right protein to the right E3 for ubiquitination.
5/ These are often called bi valent or PROTACs which stand for Proteolysis Targeting Chimera. They tend to be much larger than the monoDAC, but have more accuracy.
6/ The last one is mostly in concept, but its a trivalent protein degrader. It bind to the E3 ligase and has a linker to 2 different proteins.
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