Thread by @CoronaryDoc

Prevalence of Subclinical Coronary Atherosclerosis in General Population
@CircAHA

1/x
🇸🇪 25K randomly invited individuals w/o known CAD underwent CCTA
🇸🇪 51% women
🇸🇪 50 to 64 yrs
🇸🇪 #SCAPIS (the Swedish Cardiopulmonary Bioimage Study)

ahajournals.org/doi/10.1161/CI…

2/x
🇸🇪 42.1% any CCTA-detected atherosclerosis

🇸🇪 5.2% any significant stenosis (≥50%)

🇸🇪 1.9% LM, prox LAD or 3VCAD

🇸🇪 8.3% any non-calcified plaque

🇸🇪 plaques most common in prox LAD

🇸🇪 Participants with only non-Ca plaques were rare (2.4%)

ahajournals.org/doi/10.1161/CI…

3/x
🇸🇪 Prevalence of CCTA-detected atherosclerosis ⬆ w/ ⬆ #CAC scores

🇸🇪#CAC-positive participants:
- Most w/ low (11 - 100) or ultralow (1 - 10) scores
- median score 35 (IQR 8 - 126)

🇸🇪 participants w/ #CAC zero & interm 10-yr risk, 9.2% had CCTA-verified atherosclerosis

4/x
🇸🇪 #CAC >400:
100% (any CCTA-detected) atherosclerosis
45.7% significant stenosis

🇸🇪 #CAC 101-400:
100% atherosclerosis
24% significant stenosis

🇸🇪 #CAC 11-100:
98.7% atherosclerosis
7.0% significant stenosis
14.9% non-Ca plaques

ahajournals.org/doi/10.1161/CI…

5/x
🇸🇪 #CAC 1-10:
81.9% atherosclerosis
2.0% significant stenosis
0.5% LM, prox LAD or 3VCAD
10.5% non-Ca plaques

🇸🇪 #CAC zero:
5.5% atherosclerosis
0.4% significant stenosis
0.2% LM, prox LAD or 3VCAD
4.0% non-Ca plaques

#PowerOfZero
ahajournals.org/doi/10.1161/CI…

6/x
🇸🇪 Prevalence of atherosclerosis 1.9 X ⬆ in men vs women + ⬆ sharply w/ age in both sexes

🇸🇪 onset of atherosclerosis was delayed on average by 10 yrs in women

🇸🇪 Prevalence of atherosclerosis ⬆ w/ RF burden, 2 & 3X ⬆ in high vs low risk

ahajournals.org/doi/10.1161/CI…

7/x
🔑 ✉
🇸🇪 silent coronary atherosclerosis common in population w/o known CAD

🇸🇪 CCTA-detected atherosclerosis associated w/ #CAC score

🇸🇪 subgroups IDed whose atherosclerosis was not accurately represented by CAC showing CCTA potential additive value

ahajournals.org/doi/10.1161/CI…