A mechanistic model of the neural entropy increase elicited by #psychedelic drugs 1/5 doi.org/10.1038/s41598…
#Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consc... 2/5
iousness. One of the most notable neurophysiological signatures of #psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousnes... 3/5
s and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of #serotonergic neuromodulation, to study the en... 4/5
Date: October 2020 Authors: Rubén Herzog, Pedro A M Mediano, Fernando E Rosas, Robin Carhart-Harris, Yonatan Sanz Perl, Enzo Tagliazucchi, Rodrigo Cofre 5/5

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27 Sep
Post-#Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation 1/5 doi.org/10.3389/fpsyt.…
#Psychedelic therapy shows promise as a novel intervention for a wide range of mental health concerns but its therapeutic action is incompletely understood. In line with acceptance and commitment therapy's (ACT's) transdiagnostic model, qual... 2/5
itative research has suggested that reductions in experiential avoidance are an important component of therapeutic outcomes associated with #psychedelics. However, limited research has quantitatively explored the association between decrease... 3/5
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26 Sep
#Psychedelics and virtual reality: parallels and applications 1/5 doi.org/10.1177/204512…
#Psychedelic drugs and virtual reality (VR) each have the capacity to disrupt the rigidity and limitations of typical conscious experience. This article delineates the parallels among psychedelic and VR states as well as their potential syne... 2/5
rgistic applications in clinical and recreational settings. Findings indicate that, individually, #psychedelics and VR are used in analogous ways to alter sensory experience and evoke awe. They are also both used in tandem with traditional t... 3/5
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26 Sep
Whole-Brain Models to Explore Altered States of Consciousness from the Bottom Up 1/5 doi.org/10.3390/brains…
The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to... 2/5
different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay between large-scale connectivity and local dynamical rules that can be traced to kn... 3/5
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26 Sep
DMT alters cortical travelling waves 1/5 doi.org/10.7554/eLife.…
#Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology. N,N, Dimethyltryptamine (DMT) can rapidly induce an extremely immersive state of consciousness characterized by v... 2/5
ivid and elaborate visual imagery. Here, we investigated the electrophysiological correlates of the DMT-induced altered state from a pool of participants receiving DMT and (separately) placebo (saline) while instructed to keep their eyes cl... 3/5
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25 Sep
On Revelations and Revolutions: Drinking #Ayahuasca Among Palestinians Under Israeli Occupation 1/5 doi.org/10.3389/fpsyg.…
The ritualistic use of #ayahuasca can induce a feeling of unity and harmony among group members. However, such depoliticized feelings can come in the service of a destructive political status quo in which Palestinians are marginalized. Throu... 2/5
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25 Sep
From Psychiatry to Neurology: #Psychedelics as Prospective Therapeutics for Neurodegenerative Disorders 1/5 doi.org/10.1111/jnc.15…
The studies of #psychedelics, especially psychedelic tryptamines like #psilocybin, are rapidly gaining interest in neuroscience research. Much of this interest stems from recent clinical studies demonstrating that they have a unique ability t... 2/5
o improve the debilitating symptoms of major depressive disorder (MDD) long-term after only a single treatment. Indeed, the Food and Drug Administration (FDA) has recently designated two Phase III clinical trials studying the ability of psi... 3/5
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