An analysis of an outbreak of the Delta variant in Ontario, Canada during an indoor event shows there was no further transmission to fully vaccinated household members AND there was NO further transmission from breakthrough cases. Vaccination stopped the train of transmission.🧵
Some considerations to keep in mind. This group IS NOT eligible for COVID-19 vaccination and the outbreak occurred during an indoor high-intensity sports event. There were two distinct COVID-19 exposures on different teams with players under the age of 12. The teams did not play
against each other. Overall, 1 in 3 players on each team were infected (see infographic for more details). There was no further transmission to players on other exposed teams, OR to fully vaccinated household members. Transmission did occur from player cases to 2 of 22 household
contacts, both who were not vaccinated (under the age of 12). Investigation/tracing of the the transmission chains leading to the outbreak identified links to various social gatherings including birthday parties and weddings. Most cases in these chains were unvaccinated
individuals eligible for vaccination, that attended events while contagious (see infographic for more details) but a few were fully vaccinated “breakthrough” cases HOWEVER what is important to note is there was NO further transmission from the “breakthrough cases.”
So what does this mean? Vaccination STOPPED the train of transmission. So, let’s talk about that because there is a lot of misinformation circulating recently. “Vaccinated people are just as likely to spread the coronavirus. This misunderstanding, born out of confusing statements
from public-health authorities and misleading media headlines, is a shame. It is resulting in unnecessary fear among vaccinated people, all the while undermining the public’s understanding of the importance-and effectiveness-of getting vaccinated.”
“So let me make one thing clear: Vaccinated people are not as likely to spread the coronavirus as the unvaccinated. Even in the U.S. where more than half of the population is fully vaccinated, the unvaccinated are responsible for the overwhelming majority of transmission.”
“Despite concerns about waning immunity, vaccines provide the best protection against infection. And if someone isn’t infected, they can’t spread the coronavirus. It’s truly that simple. Additionally, for those instances of a vaccinated person getting a breakthrough case, yes,
they can be as infectious as an unvaccinated person. But they are contagious for a shorter period of time when compared with the unvaccinated, and they harbor less infectious virus overall. That’s why getting more people their shots is crucial for controlling the spread of the
coronavirus: Every vaccinated person helps limit the virus’s ability to hide, replicate, and propagate. Among the unvaccinated, the virus travels unhindered on a highway with multiple off-ramps and refueling stations. In the vaccinated, it gets lost in a maze of dead-end streets
and cul-de-sacs. Every so often, it pieces together an escape route, but in most scenarios, it finds itself cut off, and its journey ends. It can go no further. This is borne out by recent data from New York City that show that more than 96 percent of cases are among the
unvaccinated. Only 0.33% of fully vaccinated New Yorkers have been diagnosed with COVID-19. www1.nyc.gov/assets/doh/dow… Everyone knows that the vaccines help protect each individual who gets their shots. But when more people get vaccinated, this helps keep everyone else
A study out of Harvard shows while breakthrough infections with Delta have similar peak viral loads (Ct) to that of unvaccinated individuals, viral loads decrease faster in vaccinated individuals AND they are contagious for a SHORTER period of time, and harbor less virus overall.
Researchers quantified the course of viral proliferation and clearance for 173 individuals with acute SARS-CoV-2 infections using longitudinal quantitative RT-PCR tests conducted using anterior nares/oropharyngeal samples (n = 199,941) as part of the National Basketball
Association’s (NBA) occupational health program between November 28th, 2020, and August 11th, 2021. Researchers then measured the duration of viral proliferation and clearance and the peak viral concentration separately for individuals infected with Alpha (B.1.1.7), Delta
Impressive data out of Malaysia. 14.5M participants. RECoVAM study shows full vaccination reduces the risk of infection by 88% and symptomatic disease by 86%.
Overall, the COVID-19 Vaccines cut ICU Admission risk by 83% and Deaths due to COVID-19 by 88% according to the study.
ICR Director Dr. Kalaiarasu said findings by the Real-World Evaluation of Covid-19 Vaccines Under the Malaysia National Covid-19 Immunization Program (RECoVaM) showed that the overall ICU rate amongst fully vaccinated individuals-14 days after the second vaccine dose in a
Reminder: “A change in the spike protein- which allows the coronavirus to enter and infect human cells- that is radical enough to make our vaccine completely ineffective would also, almost certainly, be so extreme as to make the virus non-functional.” -Sarah Gilbert, Oxford Team
In other words, the virus cannot completely mutate as there are only so many changes the spike protein can have before it compromises its functionality and therefore its ability to bind to the ACE2 receptor on the surface of our cells and evade our antibodies at the same time.
“There aren’t very many places for the virus to go to have something that will evade immunity but still be a really infectious virus,” and therefore is unlikely to mutate into a much deadlier variant. Gilbert stated that viruses tend to become less virulent over time as they
Just a friendly reminder. Despite what you might hear, there has yet to be a variant that isn’t susceptible to the vaccines.
Why are variants unlikely to FULLY evade vaccine-induced immunity?
•Vaccines are polyclonal
•CD8+ T-cells covering 52 epitopes across the spike protein
•CD4+ T-cells covering 23 epitopes across the spike protein
“Breakthrough” infections DO NOT mean vaccines don’t work. Remember, they are preventives, NOT cures. One can still contract COVID once vaccinated. As long as that vaccine is preventing you from facing severe disease and worse, it IS working and doing what it was designed to do.
The term infection refers to the virus entering and being detectable in your system regardless of whether OR NOT it makes you sick, whereas the term illness refers to the virus entering, being detectable in your system AND making you sick. It it important not to conflate the two.
The first thing to know about the COVID-19 vaccines is that they’re doing exactly what they were designed and authorized to do. Since the vaccines first started their rollout late last year, rates of COVID-19 disease have taken an unprecedented plunge among the immunized.
A study out of RIVM (Netherlands) shows vaccine efficacy for full vaccination in regards to the Delta variant against ICU admission was 97% and against hospitalization was 95%. Vaccine efficacy was high in ALL age groups and did NOT show waning with time even after four months.🧵
In this study, researchers utilized incidence rates of COVID-19 hospitalizations and ICU admissions by vaccination status and age group to calculate vaccine effectiveness against COVID-19 hospitalizations and ICU admissions by age group, vaccine type (this study includes Moderna
Pfizer, AstraZeneca, and Johnson & Johnson), time since vaccination, and prevailing variant (Alpha or Delta). For the study period 4 April- 29 August 2021, 15,571 hospitalized people with COVID-19 were included in the analysis, of whom 887 (5.7%) were fully vaccinated.