Impressive data out of Malaysia. 14.5M participants. RECoVAM study shows full vaccination reduces the risk of infection by 88% and symptomatic disease by 86%.
Overall, the COVID-19 Vaccines cut ICU Admission risk by 83% and Deaths due to COVID-19 by 88% according to the study.
ICR Director Dr. Kalaiarasu said findings by the Real-World Evaluation of Covid-19 Vaccines Under the Malaysia National Covid-19 Immunization Program (RECoVaM) showed that the overall ICU rate amongst fully vaccinated individuals-14 days after the second vaccine dose in a
two-dose regime- stood at ONLY 0.0066%. This is equivalent to 953 ICU admissions in 14,500,984 fully vaccinated individuals tracked from April 1st to September 12th who received two doses of either Pfizer, AstraZeneca, or Sinovac. It was pointed out that 50.4% of the 953
breakthrough ICU admissions were age 60 or older and 88.6% had comorbidities. The RECoVaM study also found that breakthrough COVID-19 death rates were low among fully vaccinated individuals at 0.010% or 1,445 deaths OUT of 14.5 million individuals in the study.
Among the breakthrough mortality cases, 76.3% were age 60 or older, while 92% had comorbidities. Recipients of AstraZeneca were generally younger adults and recipients of Pfizer and Sinovac were generally older adults, including those most vulnerable.
This is data as of September 12th. The vaccines are highly effective in preventing severe disease, hospitalization, & death due to COVID-19 even in the face of the Delta variant which is currently the most prevalent variant in Malaysia.
Breakthrough ICU Rate: 0.0066% Breakthrough Death Rate: 0.010%
Dr. Kalaiarasu stated unvaccinated individuals are 11X MORE at risk of death due to the Delta variant. You can find this information here: codeblue.galencentre.org/2021/09/23/cov… and presentation here:
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An analysis of an outbreak of the Delta variant in Ontario, Canada during an indoor event shows there was no further transmission to fully vaccinated household members AND there was NO further transmission from breakthrough cases. Vaccination stopped the train of transmission.🧵
Some considerations to keep in mind. This group IS NOT eligible for COVID-19 vaccination and the outbreak occurred during an indoor high-intensity sports event. There were two distinct COVID-19 exposures on different teams with players under the age of 12. The teams did not play
against each other. Overall, 1 in 3 players on each team were infected (see infographic for more details). There was no further transmission to players on other exposed teams, OR to fully vaccinated household members. Transmission did occur from player cases to 2 of 22 household
Reminder: “A change in the spike protein- which allows the coronavirus to enter and infect human cells- that is radical enough to make our vaccine completely ineffective would also, almost certainly, be so extreme as to make the virus non-functional.” -Sarah Gilbert, Oxford Team
In other words, the virus cannot completely mutate as there are only so many changes the spike protein can have before it compromises its functionality and therefore its ability to bind to the ACE2 receptor on the surface of our cells and evade our antibodies at the same time.
“There aren’t very many places for the virus to go to have something that will evade immunity but still be a really infectious virus,” and therefore is unlikely to mutate into a much deadlier variant. Gilbert stated that viruses tend to become less virulent over time as they
Just a friendly reminder. Despite what you might hear, there has yet to be a variant that isn’t susceptible to the vaccines.
Why are variants unlikely to FULLY evade vaccine-induced immunity?
•Vaccines are polyclonal
•CD8+ T-cells covering 52 epitopes across the spike protein
•CD4+ T-cells covering 23 epitopes across the spike protein
“Breakthrough” infections DO NOT mean vaccines don’t work. Remember, they are preventives, NOT cures. One can still contract COVID once vaccinated. As long as that vaccine is preventing you from facing severe disease and worse, it IS working and doing what it was designed to do.
The term infection refers to the virus entering and being detectable in your system regardless of whether OR NOT it makes you sick, whereas the term illness refers to the virus entering, being detectable in your system AND making you sick. It it important not to conflate the two.
The first thing to know about the COVID-19 vaccines is that they’re doing exactly what they were designed and authorized to do. Since the vaccines first started their rollout late last year, rates of COVID-19 disease have taken an unprecedented plunge among the immunized.
A study out of RIVM (Netherlands) shows vaccine efficacy for full vaccination in regards to the Delta variant against ICU admission was 97% and against hospitalization was 95%. Vaccine efficacy was high in ALL age groups and did NOT show waning with time even after four months.🧵
In this study, researchers utilized incidence rates of COVID-19 hospitalizations and ICU admissions by vaccination status and age group to calculate vaccine effectiveness against COVID-19 hospitalizations and ICU admissions by age group, vaccine type (this study includes Moderna
Pfizer, AstraZeneca, and Johnson & Johnson), time since vaccination, and prevailing variant (Alpha or Delta). For the study period 4 April- 29 August 2021, 15,571 hospitalized people with COVID-19 were included in the analysis, of whom 887 (5.7%) were fully vaccinated.
A study out of the University of Edinburgh shows that vaccine efficacy against severe COVID-19 has NOT significantly decreased since Delta became the predominant variant, is around 92%, and does NOT differ significantly between AstraZeneca, Pfizer, and Moderna’s vaccines.🧵
In addition, efficacy against the broader category of hospitalized or fatal COVID-19 remains only SLIGHTLY lower for AstraZeneca’s vaccine than for the mRNA (Pfizer and Moderna) vaccines (88% versus 91%).
NOTE: The REACT-SCOT case-control study data extracted here INCLUDES cases presenting up to September 2nd, 2021, however the analyses reported here are restricted to cases and controls presenting FROM December 1st 2020 to August 19th 2021 (8 MONTHS).