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Marion Holman Profile picture
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26 Sep, 6 tweets, 1 min read
1/ Here we have Peter Attia discussing the THEORETICAL😂 possibility that lipid-lowering drugs MIGHT negatively impact cognitive function, and specifically, whether PCSK9 inhibitors had such an impact. The answer, according to him, appears to be NO. 🙄

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2/ Now I really have to wonder if Attia has some conflict of interest with Amgen, Regeneron and Sanofi since PCSK9’s reduce LDL-C by a massive 50%+. You just have to think - why did he say this ?

/3
/3 Undoubtedly, Statins prevent the body from making an antioxidant that neutralizes the damaging free radicals created by mitochondrial activity. If brain cells—which consume lots of energy—already have mitochondrial problems, then STATIN ‘ therapy’

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4/ could tip the scale and cause noticeable symptoms, such as trouble learning, cognitive issues, memory loss etc

By blocking HMG-CoA, Statins induce a decrease in cholesterol level and simultaneously other by-products of the Mevalonate pathway such as

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5/ Farnesyl pyrophosphate (FPP), geranylgeranyl pyrophosphate (GGPP), dolichols and Coenzyme Q10.

CoQ10 is a product of the Mevalonate pathway and is an important electron transporter of the mitochondrial respiratory chain. A decrease in Q10 levels, caused by

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6/ Mevalonate pathway blockade, could result in an abnormal mitochondrial respiratory function causing mitochondrial and oxidative damage.

I’m ignoring this biased study for now ⬇️

peterattiamd.com/does-low-chole…

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More from @holmanm

Marion Holman Profile picture
26 Sep
1/ Reasons why I don't trust Docs or pharma drugs:
Me age 30, diagnosed with severe Osteoporosis after a bone scan. Nurse told me I had the bones of a 70 yr old. They put me on Bisphosphonates. I researched

/2
2/ these drugs, and realised that they caused necrosis of the jaw, stomach irritation etc. Sooo I decided to do some more research, and what did I find ? Low and behold, Vitamin D3 and Vitamin K2 (MK7) puts calcium where it meant to be, in the BONES not the ARTERIES.
/3
3/ I never looked back. I've had falls from climbing, hard falls, & never broken a bone,. However a friend who has taken Bisphosphonates for the past 2 years recently had an accident. A minor fall from a restaurant stool, which resulted in a very complex break requiring

/4
Read 4 tweets
Marion Holman Profile picture
13 Sep
1/ We show that Statin-induced insulin resistance is a drug CLASS EFFECT. Cerivastatin was removed from the market because of "side effects". Our results show that Cerivastatin was the most potent Statin in promoting adipose insulin resistance.

/2
2/ "We show that statins impaired insulin-stimulated lipogenesis in an adipocyte-autonomous manner, which was prevented by supplementing isoprenoids required for prenylation". WHY ??

/3
3/ because Statins interfere with the Mevalonate pathway & deplete so many organic compounds with great structural diversity and functionality.

- and you can't always put back what Statins stole in the first place. The overriding message is
Stay away from Statins.
Read 4 tweets
Marion Holman Profile picture
9 Sep
1/ Apoptosis (cell death) is an essential component of the maintenance process of our bodies. It is a highly controlled and regulated technique for removing unwanted cells from any organ by the process of induced metabolic suicide.

/2
2/ Tinkering with this process is a potentially catastrophic game. This is the game of Russian Roulette that we play when we take Statins.
That good old law of unintended consequences could have a field day here.

/3
3/ Statins promote apoptosis. They do it in diseased tissues - Cheers for Statins. Unfortunately they ALSO do it in NORMAL tissues too; Boo for Statins.
Read 8 tweets
Marion Holman Profile picture
9 Sep
1/ Where do you find the highest concentration of cholesterol in your whole body ? YUP ! In your brain.

Although the brain represents only 2% of total body weight, it contains 20% of the body’s cholesterol. What is all that cholesterol doing up there ?
/2
2/ Synapses - where communication between brain cells takes place are lined by cholesterol-rich membranes responsible for passing neurotransmitters like serotonin, GABA, and dopamine back and forth.

/3
3/ Myelin, the white matter that insulates brain circuits, is made from tightly-wound membranes containing 75% of the brain’s cholesterol. Cholesterol also helps guide developing nerve endings to their destinations on “lipid rafts”.
/4
Read 4 tweets
Marion Holman Profile picture
5 Sep
1/ Someone sent me a DM a few days ago "what range should our cholesterol be" ? I think it’s important to stress that cholesterol reference ranges are merely an average of the general population, and that traditional populations with NO heart disease have healthy cholesterol

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2/ levels which are often much much HIGHER than the baselines for Western Societies. Reversing insulin resistance by lowering fasting blood sugar, and lowering inflammation by dietary changes is a far more sensible approach than lowering cholesterol.

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3/ Total cholesterol is a TOTALLY MEANINGLESS number, since it doesn’t tell you what that cholesterol is made up of, but guidelines say it should be around
250mg/dL - ( 6.465 mmol/l)

LDL cholesterol 130mg/dL ( 3.3618 mmol/l)

HDL cholesterol 60mg/dL (1.5516 mmol/l)

/4
Read 5 tweets
Marion Holman Profile picture
2 Sep
1/ GABAPENTIN ! Yeah another great drug according to Docs and Veterinary surgeons: "This is what I have since learned about the drug: Stanford University did a study on gabapentin in 2009 and found that it prevents the formation of new synapses in the brain.
2/ Many who take it long-term eventually develop cognitive impairment and short-term memory loss. Gabapentin affects GABA (gamma-aminobutyric acid—a “calming” element) in the body. When taking the drug, one’s body will adjust to the artificially induced GABA and start to

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3/ produce less of its own. (That fact is similar to benzodiazepines except that gabapentin affects GABA through calcium receptors rather than GABA receptors.)

Though not technically addictive, dependency can happen very quickly. If taken incorrectly, stopped abruptly,

/4
Read 6 tweets

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