Thread by @skinandall_

1. #dermatologyteaching
Let's talk about vitamins and glutathione infusion use in the skin.
Naturally, most of the vitamins we need are gotten from the diet especially in someone feeding well and is not malnourished. Glutathione is a powerful antioxidant -

2. Oxidants are produced in the body normally due to the various processes that take place. They're also important in bacterial killing. Antioxidants protect the body from oxidants especially when they're getting overwhelming. Glutathione is produced by the liver and in a healthy

3. person, your body makes enough. In people with certain conditions like liver disease or conditions where there are a lot of oxidants e.g cancers, glutathione supplementation has been documented to be beneficial.

One of the side effects of glutathione which is temporary is

4. that it lightens the skin through the inhibition of melanin production. It was not made for that purpose initially. Some studies have attempted to assess the safety of glutathione in lightening the skin in healthy subjects, but they are studies with limited sample size

5. and in some, participants dropped out due to significant adverse effects. Oral glutathione doesn't do much skin lightening because the oral formulations have limited bioavailability (not readily available for the body to use after taking).

6. So, the verdict on vitamin and glutathione infusion in healthy people who are not deficient? - Not approved for skin lightening or just rejuvenation without any deficiency as the benefits do not outweigh the risks.

Are people going to use it? - Yes

7. Are doctors going to prescribe it- Yes
Do some dermatologists support its use? - Yes.
Do I use it for my patients? - No

The most important thing is that both parties are made the decision after reviewing benefits and risks and they decided on it without coercion.

8. They're all adults. In medicine, the decision of the patient is to be respected without condescension.

More articles to read
ncbi.nlm.nih.gov/pmc/articles/P…

hindawi.com/journals/drp/2…

*make

9. In the study where 9 out of 25 dropped out, the major adverse effect was liver dysfunction.
Other reported adverse effects of glutathione as quoted from the article include adverse cutaneous eruptions including potentially fatal Stevens-Johnson syndrome (SJS)

10. and toxic epidermal necrolysis (TEN), severe abdominal pain, thyroid dysfunction, renal dysfunction, and lethal complications such as air embolism, or potentially fatal sepsis due to incorrect/unsterile method of IV administration and use of counterfeit GSH...