Viki Male Profile picture
Sep 28, 2021 9 tweets 4 min read Read on X
Let's take a look at the data from the @CDCgov ACIP meeting last week on #COVID19 #vaccine safety in #pregnancy.

It continues to be reassuring!

First, let's take a look at the new data from the V-safe pregnancy registry... 🧵

cdc.gov/vaccines/acip/…
As of the 13th September, the registry contained 5096 participants. 2/ Among 5096 people in the re...
After they have joined, the participants are interviewed in every trimester, shortly after giving birth, and again when their babies are more than three months old. 3/ Participants are interviewe...
First, they go through the data showing that, among 2456 people vaccinated before 20 weeks, the risk of miscarriage was normal.

This has been recently published and you can read about it in more detail here... 4/

But there is one additional graphic that is quite nice. This compares the week-by-week miscarriage rate in those who received the COVID vaccine, vs two studies of miscarriage rates from before the pandemic.

You can see that post-vax miscarriage rates are bang in the middle. 5/ Miscarriage rates in people...
The next section looks at outcomes for babies at birth.

The registry contains 1634 live born babies. 70% born following 3rd trimester vaccination and 30% following second trimester vaccination. 6/ Flow diagram showing that 1...
Among these babies, the rates of preterm birth, being small for gestational age, admission to neonatal intensive care and infant death are all normal. 7/ Among babies born to V-safe...
45 babies had a birth defect. The types and rates of birth defects were consistent with what is usually seen in the USA. So no evidence of an increased risk of birth defects following vaccination in this cohort. 8/ Image
That's all from the V-safe pregnancy registry! I'm off to do the school run now, but I'll be back later with an update from the Vaccine Safety Datalink... 9/9

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Viki Male

Viki Male Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @VikiLovesFACS

Feb 8
Studies looking for evidence that mRNA COVID vaccines cross the placenta have not found it (192 babies).

A case report finds degraded vaccine mRNA in umbilical cord blood from one baby, born 2d after their mother was vaccinated.

What does this mean? 🧵

ajog.org/article/S0002-…
mRNA degrades quickly, so it’s possible we haven't detected vaccine mRNA in the placenta because we didn’t look quickly enough.

To address this, the authors look at placentas for two babies born two and ten days after their mothers received a dose of COVID vaccine. 2/
The authors used a much more sensitive form of PCR than has been used in previous studies, called ddPCR. This technique also tells us whether the mRNA is intact. 3/
Read 11 tweets
Oct 23, 2023
🇨🇦 85,650 babies born after #CovidVaccination in #pregnancy vs 56,336 babies from unvaccinated pregnancies

👉🏻 Risk of death and disease lower in newborns from vaccinated pregnancies

👉🏻 No difference in hospital admission up to six months old

1/

jamanetwork.com/journals/jamap…
Image
This was designed as a safety study and the results are reassuring.

This is unsurprising, given the very extensive evidence we already have on the safety of mRNA COVID vaccines in pregnancy. 2/

docs.google.com/document/d/19F…
Image
But the finding that outcomes at birth are actually better for babies from vaccinated pregnancies is interesting!

Vaccinated families do tend to have better healthcare, but even when the study team take account of this in their analysis, the finding remains. 🤔

3/
Read 7 tweets
Sep 12, 2023
👩🏿‍🔬 RCT of Pfizer #CovidVaccine given at 24-34 weeks of #pregnancy, with babies followed to six months old.

🤰🏽 173 vaccinated vs 173 saline control

🏥 No difference in rate of severe AEs

👶🏼 No difference in babies' health at birth or up to 6 months

🧵

classic.clinicaltrials.gov/ct2/history/NC…
This came out while I was away last month, so I didn't post about it at the time. But I talk about it on @SkepticJonGuy's video released last night, which prompted me to share a few (belated!) thoughts... 2/

x.com/SkepticJonGuy/…
Some points to note! This trial is not designed to look at effects of mRNA COVID vaccination in early pregnancy.

We have some data on that from the main trials, showing no difference in pregnancy outcomes between vaccinated and control groups... 3/

fda.gov/media/152256/d…
Image
Read 15 tweets
Aug 23, 2023
🇺🇸 Yesterday, the FDA approved an RSV vaccine for use in pregnancy.

There was a non-significant difference in preterm birth in the trial, which patients will be informed about.

Let's look at the minutes of the meeting to understand these decisions... 🧵

fda.gov/news-events/pr…
Before we start, here are links to the trial report...



And the meeting minutes... 2/

nejm.org/doi/10.1056/NE…
fda.gov/media/169361/d…
RSV is the leading cause of death in babies <6 mo, and is implicated in 50% of hospitalisations for respiratory illness, so development of a vaccine is a priority.

I should declare an interest here... my baby son was very sick with RSV 😢 and I would have loved to avoid that. 3/
Read 15 tweets
May 11, 2023
@davidicke Hi David. Independently-generated data looking at safety of COVID vaccines in more than 360,000 people vaccinated in pregnancy find no increased risk of any pregnancy problems.

How do we reconcile that with the spontaneous reporting in your video?... 🧵

docs.google.com/document/d/19F… Image
@davidicke First, for context... it would probably help you to realise that those 458 spontaneous reports were out of approximately 48,000 people who had been vaccinated in pregnancy at that time. 2/

nejm.org/doi/full/10.10…

jamanetwork.com/journals/jama/…
@davidicke And these are reports of events that occurred after vaccination. There is no requirement that the events are thought to have occurred because of vaccination.

That's actually explained in the report. 3/

phmpt.org/wp-content/upl… Image
Read 8 tweets
Apr 26, 2023
@MarkWar16520311 To understand adverse effects of vaccines, it helps to think about the phases of the immune response. First, we have the innate response, which we might think of (roughly) as being inflammation. This lasts from minutes after vaccination to 48 hours-ish. 1/
@MarkWar16520311 Most adverse events happen in this timeframe and whenever we see inflammation-type symptoms (sore arm, fever, myocarditis), we should straight away be thinking: that might be the vaccine. 2/
@MarkWar16520311 Of course, some of those are so well-established (and mild) that we don't even investigate them anymore (sore arm, fever). But this logic is one of the reasons that myocarditis was taken quite seriously as a potential side effect (and indeed turned out to be one - rarely). 3/
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(