As of the 13th September, the registry contained 5096 participants. 2/
After they have joined, the participants are interviewed in every trimester, shortly after giving birth, and again when their babies are more than three months old. 3/
First, they go through the data showing that, among 2456 people vaccinated before 20 weeks, the risk of miscarriage was normal.
This has been recently published and you can read about it in more detail here... 4/
But there is one additional graphic that is quite nice. This compares the week-by-week miscarriage rate in those who received the COVID vaccine, vs two studies of miscarriage rates from before the pandemic.
You can see that post-vax miscarriage rates are bang in the middle. 5/
The next section looks at outcomes for babies at birth.
The registry contains 1634 live born babies. 70% born following 3rd trimester vaccination and 30% following second trimester vaccination. 6/
Among these babies, the rates of preterm birth, being small for gestational age, admission to neonatal intensive care and infant death are all normal. 7/
45 babies had a birth defect. The types and rates of birth defects were consistent with what is usually seen in the USA. So no evidence of an increased risk of birth defects following vaccination in this cohort. 8/
That's all from the V-safe pregnancy registry! I'm off to do the school run now, but I'll be back later with an update from the Vaccine Safety Datalink... 9/9
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mRNA degrades quickly, so it’s possible we haven't detected vaccine mRNA in the placenta because we didn’t look quickly enough.
To address this, the authors look at placentas for two babies born two and ten days after their mothers received a dose of COVID vaccine. 2/
The authors used a much more sensitive form of PCR than has been used in previous studies, called ddPCR. This technique also tells us whether the mRNA is intact. 3/
This came out while I was away last month, so I didn't post about it at the time. But I talk about it on @SkepticJonGuy's video released last night, which prompted me to share a few (belated!) thoughts... 2/
RSV is the leading cause of death in babies <6 mo, and is implicated in 50% of hospitalisations for respiratory illness, so development of a vaccine is a priority.
I should declare an interest here... my baby son was very sick with RSV 😢 and I would have loved to avoid that. 3/
@davidicke Hi David. Independently-generated data looking at safety of COVID vaccines in more than 360,000 people vaccinated in pregnancy find no increased risk of any pregnancy problems.
How do we reconcile that with the spontaneous reporting in your video?... 🧵
@davidicke First, for context... it would probably help you to realise that those 458 spontaneous reports were out of approximately 48,000 people who had been vaccinated in pregnancy at that time. 2/
@davidicke And these are reports of events that occurred after vaccination. There is no requirement that the events are thought to have occurred because of vaccination.
@MarkWar16520311 To understand adverse effects of vaccines, it helps to think about the phases of the immune response. First, we have the innate response, which we might think of (roughly) as being inflammation. This lasts from minutes after vaccination to 48 hours-ish. 1/
@MarkWar16520311 Most adverse events happen in this timeframe and whenever we see inflammation-type symptoms (sore arm, fever, myocarditis), we should straight away be thinking: that might be the vaccine. 2/
@MarkWar16520311 Of course, some of those are so well-established (and mild) that we don't even investigate them anymore (sore arm, fever). But this logic is one of the reasons that myocarditis was taken quite seriously as a potential side effect (and indeed turned out to be one - rarely). 3/