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Dr Elisa Perego Profile picture
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5 Oct, 7 tweets, 4 min read
A massive, 1 year follow-up of 150,000 covid patients and the ❤

🔥 substantial risk of cardiovascular sequelae including myocarditis, embolism: confirmed
🔥 evident risk in non-hospitalized patients, too: confirmed

Those with #LongCovid have been right since the beginning
👉 a wide range of cardiovascular disorders noted
👉 mechanisms can be multiple
👉 disease burden is vast: the authors expressly recommend policy makers to prepare for potential huge increase in patients
👉 huge control group (from existing medical records)

#LongCovid
This study (coupled with similar large-scale follow ups, for example of long-term kidney injury) provides further, overwhelming evidence that
👉SARS-CoV-2 is far from being a benign virus
👉 those with #LongCovid who've been reporting cardiovascular symptoms were totally correct
I truly hope that such strong, evidence-based analysis (yes! with control groups!) is given due consideration by policy makers, medical professionals, media outlets and governments which have recently tried to downplay SARS-CoV-2 long-term effects for mere ideology
#LongCovid
The team contributing to this study on the cardiovascular sequelae of SARS-CoV-2 have already produced a key @Nature paper on #LongCovid

nature.com/articles/s4158…
Key contributor Z. Al-Aly has also led the large-scale analysis that uncovered the significant risk of kidney damage in #LongCovid

medicine.wustl.edu/news/covid-19-…
And another study on pericarditis (cardiovascular issue) after SARS-CoV-2 infection.

Just shared by @longcovidsos

#LongCovid

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More from @elisaperego78

Dr Elisa Perego Profile picture
5 Oct
I'm truly sad to hear there are plans for covid care to be rationed in Australia.
This is what's been happening throughout the pandemic.
We need honesty from public health.
An unleashed or poorly controlled SARS-CoV-2 spread *will* bring *any* healthcare system to its knees 🧵
We saw in early 2020 Wuhan and Lombardy already how SARS-CoV-2 can literally wipe healthcare out. People were left to die at home with no care. We've seen the Italian Army bringing the coffins of covid victims out of Bergamo because the local crematorium couldn't cope.
We know SARS-CoV-2 can led to long-term symptoms and sequelae in a large percentage of those infected i.e. #LongCovid. Many of people with Long Covid aren't receiving any medical care because healthcare systems remain stretched all over the world. Some have died.
Read 5 tweets
Dr Elisa Perego Profile picture
4 Oct
An easy-to-read account of the recent paper by @resiapretorius et al. on micro-clotting in both acute and #LongCovid
In the community, we've been discussing the need to address coagulation problems in Long Covid. Not only from a research, but also from a clinical perspective!
Original scientific paper attached below 🔽
We've been discussing how some in #LongCovid with proven clotting and coagulopathy have been benefiting from appropriate treatment.
Unfortunately, not everyone has access to appropriate imaging or diagnostic

cardiab.biomedcentral.com/articles/10.11…
We need to ascertain how common these problems (coagulopathy etc.) are, which treatment could be beneficial, how care can be deployed as fast as possible for those who need it.
We have known covid is prone to clotting and cardiovascular events since early 2020!

#LongCovid
Read 5 tweets
Dr Elisa Perego Profile picture
20 Sep
Information on #LongCovid in children is available on @apresj20 website

The emerging scientific evidence shows that a non insignificant percentage of children develops long-term symptoms and sequelae following SARS-CoV-2 infection

#LongCovidKids

I share some papers 🔽 🧵
Acute kidney injury (AKI) is often associated with covid, including in children

Long-term kidney problems are not uncommon in #LongCovid

A study of hospitalized pediatric patients with AKI and lingering kidney issues after discharge 🔽

#LongCovidKids
bmcnephrol.biomedcentral.com/articles/10.11…
Evidence of lung perfusion defects and long-term inflammation was found in a 14-year-old, seven months into #LongCovid

This suggests microvascular damage and, potentially, micro-clotting in the pulmonary system, and immune dysfunction

#LongCovidKids

ncbi.nlm.nih.gov/pmc/articles/P…
Read 11 tweets
Dr Elisa Perego Profile picture
7 Sep
Yes. Many are definitely underestimating the dangers of #LongCovid and #LongCovidKids

Patients have been reporting and publishing on the gravity of the condition for over 1 year. Policy makers are still hesitant to fully acknowledge it

Thread and data collection down here 🔽
I add in my own🧵 some scientific papers and other key contributions to knowledge by patient researchers. Not exhaustive!

@fi_lowenstein @itsbodypolitic
and @ahandvanish @patientled in the NYT: the pandemic is a mass disabling event

#LongCovid

nytimes.com/2021/03/17/opi…
Davis et al (2021) characterize #LongCovid in a large cohort of patients at 7 months from symptom onset. Patients come from support groups in many different countries.

@patientled

@EClinicalMed

thelancet.com/journals/eclin…
Read 44 tweets
Dr Elisa Perego Profile picture
5 Sep
Long-term damage to the kidney is a severe effect of SARS-CoV-2 infection. It's not that rare

It often starts with little symptoms or no symptoms at all. You can end up with permanent issues

A new study is out. But kidney injury in acute and #LongCovid has been known for long
John Hopkins Medicine, for example, was discussing acute and long-lasting kidney injury after SARS-CoV-2 infection in a featured article from May 2020

#LongCovid

hopkinsmedicine.org/health/conditi…
In an article from April 2021, Zhang et al follow the recovery trajectory of 143 hospitalized covid patients with new-onset kidney disease

9% still had kidney injury four months after hospital discharge (mostly elderly category)

#LongCovid

bmcinfectdis.biomedcentral.com/articles/10.11…
Read 11 tweets
Dr Elisa Perego Profile picture
5 Sep
I disagree. It wasn't clear at all since "the beginning" that SARS-CoV-2 would have to become endemic

Making a virus as dangerous as SARS-CoV-2 "endemic" is a failure. Very poor policy making.

The countries that went for elimination, achieved elimination.

#LongCovid
Countries that managed to eliminate or strictly contain SARS-CoV-2, like New Zealand, have been put at continuous risk by poor policy making from the rest of the world.

This includes poor political and public health choices in the EU, the UK and the US.

#LongCovid
Quite a few other countries, like Italy in the first wave, came close to elimination, too

Lombardy, one of the worst hit areas in the world in 2020, managed to crush the curve despite many mistakes in active pandemic management. Yes, I was there. I speak of reality, not models
Read 4 tweets

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