Lots of interesting data in the latest ONS release.
First, reinfection rates continue to be low (though a little higher in the Delta period): they find 296 out of 20,262 (1.4%) people tested positive again, a rate of 12 per 100k person days (about 4 per year). However ...
... only 137 people (0.7%) had a Ct < 30 (i.e. high viral load) when they tested positive a second time.
Further only 88 people (0.4%) reported any symptoms (see Table 1d) ...
... Second, the chance of reinfection increases somewhat over time, but remains very low even after a year.
e.g. Table 2c gives estimated reinfection rates per 100k person-days = 10.8 one year after the 1st infection ...
... and just as striking is that vaccination is not estimated to have any statistically significant effect on re-infection.
Note mid-point estimate < 1, so vaccination may have a modest additional effect, but 95% c.i. suggests we can't rule out that there is no effect at all ...
... Given growing evidence of significant vaccine effectiveness, it is looking increasingly likely that an unvaccinated person with a previous infection (even a year ago) is much less likely to get infected than someone vaccinated, say, 6 months earlier ...
...
Worth noting this is not an estimate of vaccine effectiveness as such, but an estimate of actual reinfection probability.
This may be influenced behavioural effects & other factors but it is these real world infection rates that are relevant for vaccine passports etc ...
...
Taken together, how can any Govt minster look at these data & think banning previously infected people from football & nightclubs or sacking them from their caring or nursing job will have a public health benefit?
(just for the clarity, discriminating against or sacking *any* unvaccinated person is unethical & also unlikely to have any significant public health benefit. It is just the case for targeting those who have been previously infected is completely non-existent)

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More from @cricketwyvern

4 Oct
Vaccine passports are unethical, unlikely to lead to any significant benefits & will cause huge costs. But they have another significant problem:
Under the Govt’s Plan B, the conditions for bringing them in will only happen if (ironically) vaccines are not working well.

The Govt says vaccine passports are being kept in reserve for a situation in which the NHS comes under *unsustainable pressure*.

So what are the circumstances in which that might happen? …

In July England opened up at the peak of a pretty big outbreak: positive tests reached 80% of the highest ever point last winter &, for some age groups & areas, much higher than the winter peak...
Read 11 tweets
30 Sep
Important new peer-reviewed paper on lockdown cost-benefits by Professor Douglas W Allen of @SFU published in the International Journal of the Economics of Business (I am a co-editor) @Routledge_Econ

Currently free to access here:
...
tandfonline.com/doi/pdf/10.108…

Using the "mid-point estimates", Prof Allen finds a cost-benefit ratio of about 140 (i.e. costs of lockdown were 140 times greater than benefits).

Even with the most extreme & unrealistic assumption about deaths averted by lockdowns, costs still outweigh benefits …

Note the mid-point estimate assumes lockdowns reduced Covid deaths by 20%.
In fact, Prof Allen concludes we cannot rule out that lockdowns had zero effect on mortality, in which case, the cost-benefit conclusion would be much worse …
Read 7 tweets
28 Sep
Data from Scotland provides enough evidence to delay enforcement of high-cost low-benefit vaccine passport not just for 17 days but indefinitely …
news.sky.com/story/covid-19…

On 6 Sep, daily positive test rate was 117 /100k, 2.7 times the Jan peak.

Despite that, deaths peaked on 16 Sep at 20.4 /day, just 30% that in Jan & now dropping.

i.e. despite an unprecedented peak in cases, Scotland didn’t come close to Jan death numbers.… ImageImage

Note, there were record positive test rates (but not deaths) even for over 60s despite close to 100% vaccination rate.

Vaccination of vulnerable reduces deaths but higher vaccination rates are clearly not the magic bullet for preventing big infection outbreaks … ImageImage
Read 5 tweets
24 Sep
Let's not dismiss concerns that PHE report some vaccinated groups getting infected at higher rates than unvaccinated.

First, even if vaccines significantly reduce chance of infection (high vaccine effectiveness), real world data may not reflect this for several reasons ...

Vaccinated may behave differently to unvaccinated, e.g. taking more risks &/or ignoring low level symptoms.
Also, there may be population differences, e.g. previously infected with very high levels of immunity could be less likely to get vaccinated ...

Irrespective of the reasons, if real world infection rates among vaxed are higher (or not much lower) than unvaxed, vaccines may still be helpful in reducing hospitalisations & deaths but there should be serious questions about vaccine passports, sacking carers etc. ...
Read 11 tweets
15 Sep
Update to various Covid-19 indicators for England:
• Deaths up again (data to 9 Sept) but looks like will turn back down from tomorrow.
• Admissions coming down faster now.
• Positive tests also falling quite fast, both school age & others.
• Triage & Zoe steady. Image
What is particularly encouraging for future hospitalisation and deaths data is that positive tests are at long last falling steadily in the 60+ and 90+ groups ...
...
Encouraging also that school age rates are decreasing *despite* (!) no masks.
Mass school testing makes interpreting trends a little tricky, but no obvious signal from the positive tests data of any significant increase in infections after schools opened in England ...
Read 4 tweets
14 Sep
The Govt seem to have authorised vaccinating 12-15 year olds on the basis of modelling suggesting the programme will avoid the loss of about 15 minutes schooling per pupil over a 6 months period.

But even that 15 minute benefit assumes ...
gov.uk/government/pub…
...
1. No vaccinated children have been previously infected.

But we know a high % of children have been infected & hence already have high immunity. Allowing for this wd mean estimated schooling saved is much lower even than 15 mins /pupil.

But also ...
...
2. The modelling assumes no school time is lost administering the vaccine.

If children are vaccinated at school & then observed for 15 minutes (as advised), the whole 15 minutes benefit would be more than wiped out.

But it gets worse ...
nhs.uk/conditions/cor…
Read 6 tweets

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