“The vaccines don’t work- look at Singapore.” Alright, let’s do it.
Cases are at record highs due to Delta, however, OVER 98% of Singapore’s vaccinated cases are MILD or have NO symptoms. In addition, the nation has had VERY FEW deaths despite a surge in cases.
I’m not done.🧵
As of Tuesday, 83% of Singapore’s population is considered to be fully vaccinated. TO NOTE: Singapore recently transitioned away from a Zero COVID approach. The rise in cases upon attempting to reopen was to be expected as part of attempting to “live” with the virus and reopen.
According to their MOH, over the last 28 days, of the 43,610 infected individuals, 98.3% are MILD or have NO symptoms, 1.4% required oxygen supplementation, 0.1% required ICU care, and 0.2% had died. moh.gov.sg/news-highlight….
Singapore reports vaccine effectiveness of 69% against ANY infection, 80-90% against symptomatic disease, 93% against severe COVID-19 that requires oxygen supplementation, ICU admission, and death. Most Singaporeans have received Pfizer’s and Moderna’s vaccines.
As of yesterday, 3 more cases had passed away from complications due to COVID-19 infection. According to the MOH, the individuals were aged between 68 and 102 years. All of them had been unvaccinated against COVID-19, and had various underlying medical conditions.
So why are they seeing these numbers? Let’s break this down. “Hospital beds are filling up because of the country’s “very cautious” approach, and NOT because that many people need acute medical care,” according to Teo Yik-Ying, dean of the Saw Swee Hock School of Public Health
at the National University of Singapore. “Case numbers may remain high for a few months, but the “vast majority” will be well protected by the vaccines and won’t fall seriously ill.” “The long-term plan against COVID is a combination of vaccination and natural infection to
provide protection while not overwhelming hospitals,” he said, adding that he does “not anticipate an increase in the death rate, but the absolute numbers can be expected to rise.” The majority of Singapore’s numbers therefore can be attributed to nervous residents with LITTLE or
NO symptoms overwhelming hospitals. “The resulting high numbers are causing a lot of anxiety and worry. People are flooding hospitals and GP clinics. This affects healthcare manpower as staff are quarantined and wards shut down.” A policy of mass testing asymptomatic people,
many of whom rush to hospital after a positive, even if free of symptoms are currently what is driving Singapore’s case numbers. “Instead of infection followed by vaccination, we’re going to go vaccination followed by infection, which I think is even better because [infections]
will mostly be mild,” said Ooi Eng Eong, a professor in Duke-NUS Medical School’s emerging infectious diseases program. Experts also say that Singapore's climbing cases, more than half of which are in vaccinated individuals, may signal that COVID-19 is becoming an endemic disease
in the city-state, meaning COVID-19 circulates in a population like its four coronaviruses cousins but doesn't upend lives due to widespread immunity. As long as deaths remain low, Singapore can set an example for how other countries, especially those that have maintained zero
“Breakthrough” infections DO NOT mean vaccines don’t work. Remember, they are preventives, NOT cures. One can still contract COVID once vaccinated. As long as that vaccine is preventing you from facing severe disease and worse, it IS working and doing what it was designed to do.
Regarding the concerns about waning immunity. Please remember, this is likely referring to infection. NOT effectiveness against symptomatic infection, NOT effectiveness against severe illness. While neutralizing antibodies decrease over time (as they ARE supposed to) protective
immunity provided by memory B-cells and T-cells is STILL present. Remember: Immunological memory consists of antibodies, memory B-cells, memory CD8+ T-cells, and memory CD4+ T-cells. These responses give us enduring protection even against newly emerging SARS-CoV-2 variants.
This has not been shared widely in the media so let’s fix that. COVID-19 is now in retreat in the United States, the United Kingdom, AND Worldwide. Worldwide, cases have fallen MORE THAN 30% since late August and weekly deaths have fallen MORE THAN 15%. It gets better. Read on.🧵
•U.S. cases and hospitalizations have fallen 35% and 25% respectively since September 1st.
•Daily deaths in the U.S. have fallen 10% since September 20th. It is the FIRST sustained decline in deaths since the early summer.
•Deaths in the U.K. have fallen 21% since their-
September peak.
•Hospitalizations in the U.K. are down 28% since their September peak.
•The pattern has also been evident within countries, including India, Indonesia, Thailand, Britain, France, and Spain. In each of them, the Delta variant led to a surge in cases lasting-
An analysis of an outbreak of the Delta variant at nine summer youth camps in the United States shows there was NO further transmission to fully vaccinated individuals AND there was NO further transmission from breakthrough cases. Vaccination stopped the train of transmission. 🧵
This case study assessed the number of COVID-19 cases and potential secondary spread among 7,173 staff members and campers from 50 states, 13 countries, and U.S. military overseas bases at nine independently operated U.S. summer youth camps affiliated with the same organization.
Some considerations to keep in mind: some members of these groups WERE NOT eligible for COVID-19 vaccination. Three of the nine cases occurred in vaccinated staff members and six in unvaccinated campers aged 8–14 years. It is ALSO important to note that at some camps physical
So, not COVID-19 related, however, this is really exciting news I wanted to share. Phase I trials of Moderna's HIV vaccine candidate, mRNA-1644, which uses the same mRNA technology as our COVID-19 vaccine, is expected to begin clinical trials this month!
Approximately 38 million people worldwide are currently living with HIV with 1.2 million in the U.S. Approximately 2 million new infections of HIV are acquired worldwide every year and approximately 690,000 people die annually due to complications from HIV/AIDS.
mRNA-1644 is a novel approach to HIV vaccine strategy in humans designed to elicit broadly neutralizing HIV-1 antibodies (bNAbs). The Phase 1 study for mRNA-1644 will use iterative testing to validate the approach and antigens and multiple novel antigens will be used
A 50,000+ study out of the University of Oxford shows while “breakthrough” infections with Delta have similar viral loads (Ct) to unvaccinated individuals, vaccination DOES REDUCE transmission of Delta and vaccinated individuals are LESS LIKELY to spread the Coronavirus. 🧵
Pre-Delta, vaccination reduced transmission of SARS-CoV-2 from individuals infected despite vaccination, potentially via reducing viral loads. While vaccination still lowers the risk of infection, similar viral loads in vaccinated and unvaccinated individuals infected with Delta
question how much vaccination prevents onward transmission. Researchers here performed a retrospective observational cohort study of contacts of SARS-CoV-2-infected index cases using contact testing data from England. They used multivariable logistic regression to investigate the
Portugal, a country who once had the world’s highest number of COVID-19 cases proportionate to its population, now has the world’s HIGHEST vaccination rate. 84% of Portugal’s population is now fully vaccinated. The country will lift most pandemic restrictions on October 1st.
Note: That is 8.5 million people fully vaccinated, and this has been in a matter of months. The nation went from vaccinating only 7000 citizens a day in January, to three months later 44,000 daily doses in April, and 150,000 doses PER DAY at its vaccination peak on July 12th.
In just a few days, nightclubs and bars will be allowed to reopen to those with a digital vaccination certificate or negative COVID-19 test, after having been shut since March 2020. Digital certificates or negative tests will no longer be mandatory in hotels and gyms, but will