I am quite surprised by @angie_rasmussen's comment yesterday at the 7 Oct BMJ webinar
(video: and webpage: bmj.com/covid-19-webin…)
1/
First, the "Calisher paper" should rather be named the "Daszak paper" as it was found out afterwards by @USRTK that Daszak was the lead author or coordinator of the effort, although he didn't appear as first author - usrtk.org/biohazards-blo…
2/
This Lancet paper stated: "We stand together to strongly condemn conspiracy theories suggesting that COVID-19 does not have a natural origin."
thelancet.com/journals/lance…
3/
This was shocking to many of us who use the scientific method to confront arguments, as there was no strong evidence at the time to discard a possible lab accident.
4/
We wrote to The Lancet asking them for an open discussion. The Lancet rejected our request.
5/
disinformationchronicle.substack.com/p/we-can-speak…
Several rebuttal Letters were sent by various scientists to diverse scientific journals in 2020 and early 2021 to challenge the exclusive focus on the zoonosis hypothesis. None were accepted.
More details here: normalesup.org/~vorgogoz/arti…
6/
Meanwhile .@angie_rasmussen participated in several articles dismissing "the lab leak theory" (as she calls it on Twitter). This one in @NatureMedicine uses particularly fallacious arguments:
nature.com/articles/s4159…
7/
-> she combines all "lab leak theories" into one category: "contradictory and sometimes outright ridiculous conspiracy theories that spread faster than the virus itself", "laboratory accident or was intentionally engineered" "Bill Gates, the CCP & 5G wireless network"
8/
-> her arguments cannot exclude a possible lab accident with a natural sample collected by researchers.
9/
As explained in our 3rd open letter, several lab-related accident scenarios are possible:
10/
researchgate.net/publication/35…
There is also a lot to say about the "Critical review" that @angie_rasmussen co-authored in @CellCellPress : biases, cherry-picking, errors.
ncbi.nlm.nih.gov/pmc/articles/P…
11/
@Ayjchan wrote a very good response to Holmes et al "Critical review" in @Medium
ayjchan.medium.com/a-response-to-…
I hope that other articles will be published to challenge the @CellCellPress "Critical review".
13/
And now on 7 Oct 2021, @angie_rasmussen wrote: "Nobody credible has dismissed the possibility of laboratory origin.".
14/
Well, you @angie_rasmussen participated in shutting down the debate in the scientific community and made it very difficult for scientists to argue that we still need more evidence before concluding that the virus is fully natural.
theconversation.com/covid-19-why-t…
15/
If you really believe that "Nobody credible has dismissed the possibility of laboratory origin", you should have supported @DrTedros who repeatedly asked for a credible investigation and to follow the science.

who.int/news/item/30-0…
who.int/fr/news/item/2…
16/
.@R_H_Ebright mentioned the possibility of a lab accident in the early days of the COVID-19 pandemic in January 2020 in @ScienceMagazine

science.org/content/articl…
17/
yet some scientists (including you @angie_rasmussen) were very powerful at closing the debate.
At least there are now 2 papers published in top scientific journals which note that we still don't know whether the virus has a lab accidental or a fully natural origin.
18/
The first one in 14 May 2021 in @ScienceMagazine by @jbloom_lab et al.
science.org/doi/10.1126/sc…
19/
The second one in 17 Sept 2021 in @TheLancet by van Helden et al.
thelancet.com/journals/lance…
20/
Such articles should have been published in the early days of the pandemic, but it took more than a year. This is not acceptable. Let's hope that these problems with scientific publishing will now be fixed.
21/
.@andyaschmidt @bertahidalgo @DrKatEpi @timothysheahan & others:
please read ⤵️
nature.com/articles/s4159…

& ask yourself: what does this paper do with the lab accident hypothesis? And does it propose a thorough investigation of all hypotheses?

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More from @Biol4Ever

2 Aug
@TheSeeker268 ZL Shi indicated in July 2020 in Science that the 5' end of RaTG13 was missing from their sequence: sciencemag.org/sites/default/…
@TheSeeker268 Note: how did they know that the missing 5' piece was 15 nucleotide long in July 2020?
@TheSeeker268 and then, on 13 October 2020 the missing 15bp appeared in NCBI, with no explanation & no supporting raw data
ncbi.nlm.nih.gov/nuccore/MN9965…
as noticed by @Ayjchan
Read 5 tweets
10 May
@K_G_Andersen Thank you so much for taking the time to lay down your arguments about this furin cleavage site. This is very useful and highly needed.
Yes, there is one aspect that you are missing, which has been bothering me:
1/
@K_G_Andersen This FCS was noted as "cleavage site" in a January 2020 publication by Zheng-Li Shi and colleagues (before the Nature paper):
"we predicted that the cleavage site for generating S1 and S2 subunits is located at R694/S695"
ncbi.nlm.nih.gov/pmc/articles/P…
2/
@K_G_Andersen Note that the correct position of the R/S furin cleavage site is 685/686 and not 694/695. There is no other RS amino acid sequence in the neighboring region so this "R694/S695" points to the furin cleavage site.
3/ Image
Read 8 tweets
1 Feb
One of the best papers I read in the last few years:
Sudhir Kumar @cathyqqtao @stvnwvr @sergeilkp & al.
reconstructed virus evolution using cancer mutation lineage tracing approach @TempleUniv
@biorxivpreprint

biorxiv.org/content/10.110… Image
The authors examined #SARSCoV2 evolution and found that all sequences originate from
proCoV2, the mother genome of all #SARSCoV2 sequences.
The reference SARSCoV2 sequence from 24 December (Wuhan‐1;EPI_ISL 402123) has 3 mutations compared to proCoV2.
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The progression from proCoV2 to Wuhan-1 via 3 successive mutations is supported by >850 intermediate genomes.
The mother genome was detected in China and USA until March 2020.
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