At the same time, vaccinated individuals are less likely to be admitted to hospital, or die from COVID-19.
The reported death protection is likely to be an underestimation, because vaccination preferentially occurs among people who have more background illnesses.
2/
The question is why the rate of infection is higher among vaccinated people.
It is obvious by now that vaccines aren’t very good at stopping the virus from entering the nose or throat, particularly past the initial few weeks of high antibody titres.
3/
Long-lived mucosal immunity is not adequately generated by these injectable vaccines, while systemic immunity against organ damage is very good.
That’s why hospitalisation is substantially lower among vaccinated people.
4/
As to why vacccinated people are testing positive, it is also possible that vaccinated people socialise more - because they feel confident and enjoy greater access public places, but that’s speculative.
5/
As to why children aren’t testing positive, it could be that the vaccination was more recent (hence they are still in the “superhigh” window of antibodies)
Testing strategies could be different for these age groups, e.g. unvaccinated children could be getting tested more.
6/
These data must be used constructively to modify public health strategies, in particular the concept of vaccine passport, as many of us had written earlier, is invalid.
A careful watch has to be maintained long-term for any [real] decline in protection from severe disease.
7/7
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Whether Children should be vaccinated before attending school is a topic where not everyone agrees upon.
In other words this is not a binary topic; which means that a “yes or no” answer is not relevant.
That is why the opinion of doctors who take care of patients matter.
2/
Experience in my part of India on the ground has overwhelmingly stated the following facts.
1. Regardless of what immunology says, the chance that a child will fall sick from COVID-19 is so rare - it is much rarer than chance of death from many routine things in life.
3/
When we view the outside world while standing in the ICU, it is easy to be tricked into believing that the whole world is falling severely ill.
It is true that a tiny % of children fall ill, but that % is less than 0.008 (Kerala) and is ~made up of children with comorbidity.
2/
Which is why if we only look at the severely ill children, we will not be able to see the massive denominator of healthy children who were not affected significantly by the virus.
3/
Optimal T cell response was detected - that is CD4 Th1 and CD8 with a high degree of polyfunctionality, covering a broad range of spike protein epitopes.
2/
This increased T cell breadth will help fight variants. In other words, a few viral mutations here or there will not make a difference to these T cells.
This means the virus will continue to be hunted down even if it modified its appearance to gain entry into the body.
3/
Such measures, taken by several nations in 2020, were justifiable due to a fear of the unknown. Now that we have 21 months of data, it is time to sit down & see if they made any difference.
We must also not forget that it is the SAME virus, regardless of fancy Greek names.
2/4
The problem with variants of concern is two-fold.
1. They take a long time to show their true colours. Thus, by the time they are declared as VOC, modern travel would have taken them all around the world.
2. Even a single introduction is enough to infect a whole country.
3/4
This thread shows instances of fully vaccinated people picking up (and spreading) infections. Apart from very low baseline risk, this is one more good reason why universal COVID vaccination for healthy children isn’t advisable. See UK study linked below. @GKangInd@doctorsoumya