Google Enformer is one of the greatest accomplishments of the highly accomplished @deepmind team

It could impact the field of genetics profoundly

It has improved the prediction of gene expression 1/3rd of the way towards experimental ground truth…
Before Enformer, tools such as Basenji2 used convolutional neural networks

These struggle to incorporate information from distant regions in the genome 🧬

Enformer uses a modified transformer architecture

It has a field of view 5x Basenji2
The full text of the paper is available on biorxiv

“these advances will enable more effective fine-mapping of growing human disease associations to cell-type-specific gene regulatory mechanisms”…
Amazing work by @Avsecz, @drklly, @vagar112, @iassael, @pushmeet

Also great coverage by @ARKInvest & @sbarnettARK

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More from @aakashg0

12 Oct
Flesh out your ideas to improve your blog posts. Longer posts tend to do better

But how do you deal with readers who have limited time?
2 techniques 🧵:
1. The article summary
2. Compulsive readability Image
1. The article summary
Summarize your entire article in 500 words after writing it. Then re-write the hook two times.

This is your article summary. You can start a longer blog post with it

Bonus: Great fodder for social shares. You may even rewrite your title as a result
2. Compulsive readability
Give readers a reason to keep on reading all the detailed work you did. Do original work even!

-Write in a compelling way. Leave crucial details unsaid.
-Write surprisingly. Drop in details that make readers want to figure out the layer deeper
Read 4 tweets
12 Oct
The Race car growth framework
⚙️ The (Growth) Engine
💥 Turbo Boosts: One-off events
💧 Lubricants: Optimizations
⛽ Fuel: Input

How can you turbo boost your product?

An awesome piece from @abouelatta_ali & @lennysan on just that this week. My summary:
There are seven common types of Turbo Boosts
1: Viral video
2: Mini-product
3: Limited time offer
4: Influencers
5: Co-marketing
6: Offline experience
7: Picking a fight

Each one is interesting 👇
1: Viral video
Startups like GoldieBlox, Monet, Dropbox, Poo-Pourri, Man Crates, mmhmm, and Dollar Shave Club released viral videos that helped turbo boost growth

Surprise, mystery, controversy, being personal, being different, and having an impressive are the recipe ingredients
Read 11 tweets
12 Oct
🔥 private session with build a second brain founder @fortelabs. My top 7 learnings 🧵👇:

1. The 1000 step, not 30 step, journey 🛣️
You are closer to the starting line than you think

Writing is a longevity game: only see 20-30 steps of your idols, but they had 100s or 1000s
2. People are too strategic to early ⚽️
Stop switching & try to optimize a strategy

In early days, it's just volume. Looking for 400-500 shots on goal writing online, not 40-50

Every iteration is a shot on goal
3. Treat everything as a small project 🗒️
Writing a book feels like years of your life

But project managing - the quintessential life cycle - into small projects, like 20-30 becomes a manageable chunk

Now he's completed his manuscript
Read 8 tweets
10 Oct
The archetypal product growth examples are outdated

Dropbox is not growing that fast anymore. Uber, Docusign, and Zoom are growing a lot through sales & marketing as well

Product rockets 🚀, a 🧵 Image
Every product person has heard it in their job: X competitor has released X feature. We should too!

But how do we know what companies are actually growing through product NOW?

I propose revenue growth rate & product : sales & marketing spend as two metrics. Image
So, I got together companies:
- Most written about: Airbnb, Ube, & Dropbox
- Buzzy growers: Robinhood, Atlassian, Snowflake, Square & Shopify
- Focused mid-caps: Snap, Datadog, Docusign, Servicenow & Zoom
- Mega-caps: Alibaba, Microsoft, Google & Facebook
- The original: PayPal Image
Read 6 tweets

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