CDI is epidemic level, especially in #IBD 
CDI can be disease defining in #IBD
Diagnosis is even trickier in #IBD
Need to know which test your institution offers
Treatment of CDI in #IBD has additional considerations
Metronidazole is inferior in the treatment of hypervirulent strains of C. difficile
@DrJessicaA: "I consider #IBD a marker of severity of C. difficile infection."
Do. Not. Use. Metronidazole!
Do. Not. Use. Metronidazole!
Need to treat BOTH CDI *and* #IBD flare.
Bezlo is for PREVENTION of recurrence, not treatment. Should be given during treatment of CDI.
SIGNIFICANTLY decreases rCDI, especially in #IBD
SIGNIFICANTLY decreases rCDI, especially in #IBD
#FMT is a drug and a biologic
#FMT is well established in rCDI
Specifics of #FMT
#FMT does not have major safety concerns to date, but 2 cases of new onset ulcerative colitis have been reported. Interest into looking at longer term consequences such as autoimmunity, Parkinson disease, etc.
#FMT exceedingly effective for rCDI
Very few rCDI, and vast majority were decolonized
CDI treatment in #IBD
Take home points from @DrJessicaA
• • •
Missing some Tweet in this thread? You can try to
force a refresh
