Thread by @BillyBostickson

The Good, Bad & the Ugly with @THAILANDMEDICA1
1. thailandmedical.news/news/breaking-…

Paper: COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes

insight.jci.org/articles/view/…

2. Does your Brain hurt?

thailandmedical.news/news/saudi-ara…

Paper: Brain MRI in SARS-CoV-2 pneumonia patients with newly developed neurological manifestations suggestive of brain involvement

nature.com/articles/s4159…

3. Yes, my brain hurts, doctor!

thailandmedical.news/news/breaking-…

Paper:

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

nature.com/articles/s4159…

4. Cognitive Decline and Brain Fog

thailandmedical.news/news/icahn-stu…

Paper: Assessment of Cognitive Function in Patients After COVID-19 Infection

jamanetwork.com/journals/jaman…

4. You Microclot! You Inflammatory Molecule!

thailandmedical.news/news/breaking-…

Paper: Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

cardiab.biomedcentral.com/articles/10.11…

5. Deviled Kidneys?

thailandmedical.news/news/more-grea…

Paper: Kidney Outcomes in Long COVID

jasn.asnjournals.org/content/early/…

jasn.asnjournals.org/content/jnephr…

6. We are all effed?

thailandmedical.news/news/breaking-…

Paper: Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection
A Systematic Review

jamanetwork.com/journals/jaman…

n this systematic review of 57 studies comprising more than 250 000 survivors of COVID-19,

7. How dare you alter my Genes without permission!

thailandmedical.news/news/breaking-…

Paper: Acute COVID-19 gene-expression profiles show multiple etiologies of long-term sequelae

medrxiv.org/content/10.110…

8. New Variants and Mutations (1)

You can run but you can't hide..

thailandmedical.news/news/breaking-…

Paper: The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency

nature.com/articles/s4142…

9. New Variants and Mutations (2)

SARS-COV-2 gets a Break out of Jail Free Card

Hotspot Mutations and Immune Evasion

thailandmedical.news/news/swiss-stu…

Paper: Mutational hotspot in the SARS-CoV-2 Spike protein N-terminal domain conferring immune escape potential

biorxiv.org/content/10.110…

10. New Variants and Mutations (3)

Baton Rouge Mutants

thailandmedical.news/news/louisiana…

News: What do we know about the new Louisiana COVID-19 variant?

deseret.com/coronavirus/20…

11. New Variants and Mutations (4)

Don't go to Cape Cod

thailandmedical.news/news/harvard-a…

Paper: Evidence of transmission from fully vaccinated individuals in a large outbreak of the SARS-CoV-2 Delta variant in Provincetown, Massachusetts

medrxiv.org/content/10.110…

12. Oi, Pfizer, did you just steal my N Antibodies?

thailandmedical.news/news/uk-health…

with useful list of 91 studies on natural immunity

Document (UK):

assets.publishing.service.gov.uk/government/upl…

13. Single agent monoclonal antibodies? Hilarious?

@THAILANDMEDICA1 puts the boot in again(Image 1)
thailandmedical.news/news/hilarious…
Paper: Acquisition & onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab-treated patient
medrxiv.org/content/10.110…

14. One for @Daoyu15 Too complex for me.

Monoclonal Antibody Related

thailandmedical.news/news/breaking-…

Paper: Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis

biorxiv.org/content/10.110…

15. Role of Lipids

thailandmedical.news/news/universit…

Paper: The roles of lipids in SARS-CoV-2 viral replication and the host immune response

jlr.org/article/S0022-…

16. "Palmitoylation" 🤲🤦🤦‍♂️🤦‍♀️

thailandmedical.news/news/universit…

Paper: Inhibition of SARS-CoV-2 spike protein palmitoylation reduces virus infectivity

biorxiv.org/content/10.110…

"Palmitoylation of the 1st 5 cysteine residues of the spike c-terminal cysteine-rich domain are indispensable"

17. Finished with Bad & Ugly, now Good news
1. Manuka Honey
thailandmedical.news/news/qatar-uni…
2. Basil (Fenchol)
thailandmedical.news/news/fenchol-a…
3. Glucose Regulating Drugs
thailandmedical.news/news/penn-stat…
4. Zofran (Antiemetic)
thailandmedical.news/news/new-ameri…
5. Atovaquone (antimicrobial)
thailandmedical.news/news/danish,-c…

18. I hope this thread was not too depressing?

If it was, the solution is at hand, mushroom soup :)

thailandmedical.news/news/penn-stat…

Mushroom intake and depression

"Mushroom consumers had a lower odd of depression"

sciencedirect.com/science/articl…

unroll the good, bad and the ugly @threadreaderapp