As many of you know, we're conducting a study on #LMHRs (link later in thread) who not only have extremely high #LDL#Cholesterol, but many (likely most) have diets quite contrary to this advice by the @American_Heart.
2/ First, and most importantly, we do not know what the outcome of this prospective study is. So while I'll be outlining commonalities we observe with #LMHRs, this isn't an explicit endorsement of the diet nor any altered lipid levels as a result.
With that said...
3/ We have a lot of data between our standing survey, submissions to CholesterolCode.com, and CC and LMHR Facebook groups (7.7k and 7.5k members, respectively).
Diets are often: 1) Low to no fruits & veg 2) Low to no grains 3) High animal protein 4) Low in plant oils
4/ @NutritionMadeS3 points to an especially strong statement in the paper:
I'm a bit surprised by this statement given how much data we have with @virtahealth at this point, particularly with regard to high risk populations and ASCVD outcomes on #keto.
5/ But that said, it's certainly true we don't have data on *low risk* populations and progression of #atherosclerosis, particularly longitudinal, where consuming a diet considered suboptimal (or even overtly dangerous) by many nutrition experts today.
It's well past time we look to the populations of interest directly.
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<Naturally, I should insert the obligatory plug here: please contribute to CitizenScienceFoundation.org to complete our funding for this study - we're almost there!>
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I now suspect #PlantBasedLowCarb (PBLC) isn't as low carb as originally thought.
Before getting started in this thread, I should emphasize I wouldn't consider this a good or bad thing in and of itself, but it is of interest, ofc...
2/ Moreover, I've regularly pointed to people following my work who are both (1) very interested in a low carb diet, but (2) would prefer to keep their #LDL low to consider PBLC as a "third option", as I commonly see it associates with this outcome.
Now to my hypothesis...
3/ PBLC generally has two major features separating it from "typical" #keto/#lchf:
1) More fat sourced from mono and polyunsaturated fatty acids (M/PUFA) instead of saturated fatty acids (SFA)
2) A lot more soluble and insoluble fiber via plants
2/ Imagine a room full of people at tables being served with trays of food regularly coming from the kitchen moved around the room by waiters.
No one is particularly famished, but they aren't especially full either, so they are absently taking food off the trays to maintain...
3/ However, a few guests at one table leave to get some exercise and return quit hungry.
And here's the catch: You can't tell specific people to do specific things (including the waiters), but you can say things to the entire room. Is there a way to solve this puzzle?
1/ Okay, finally getting around to this experiment video by @ScepticalDoctor
Naturally, this has many things I'm interested in -->
- N=1
- #Lipids (esp #Cholesterol)
- and not least of all, Anna and I have many respectful, kind debates (more of that plz, #NutritionTwitter)
1/ Yes, my answer to the poll by @nicknorwitz was "Gain 4% body fat". And honestly, it was a pretty easy one when compared to the others.
But to be fair, I also have quite a bit of direct data on this in particular... let's unpack...
2/ First, if you didn't already know this about me, in 2018 I literally gained almost 20lbs of fat for the Weight Gain Experiment. cholesterolcode.com/weight-gain-ex…
(As an aside, I realize now I did presentations on the findings for this experiment, but didn't do a write up. Bad Dave!)
3/ But spoiler alert -- my total and LDL cholesterol did indeed go down where having gained weight and back up where having lost it.
To be sure, I think there are thresholds to "active fat gain/loss" vs standing, stable fat mass, but we'll save that for another thread.
I'm going to provide some updates and answers to frequent questions of the last several days...
2/ "Dave, can you get me in the study?"
No! You have to contact Lundquist directly through the proper channels and they will decide based on the study design whether you qualify as prescribed by existing eligibility criteria we all determined in advance.
3/ While myself, @DrNadolsky and @DrRagnar developed the protocol in collaboration Lundquist, we in no way can (or should) influence any decision making regarding individual considerations -- and that's a good thing. We want this study as fair and objective as possible.