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Dr Elisa Perego Profile picture
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4 Nov, 4 tweets, 4 min read
As expected, children in the UK are increasingly impacted by #LongCovid

Almost 70,000 are reported to have #LongCovidKids in early October 2021

10,000 to have been ill for at least one year

Official @ONS data out now | in keeping with the growing biomedical literature
I am curating a 🧵 on scientific papers on #LongCovid in children #LongCovidKids

Not complete! But enough biomedical research and clinical data to confirm what the @ONS from the UK are telling us. Children are impacted by Long Covid

Thanks @apresj20

@FranceskoNew @docdrugztore
Pediatric deaths are also on the rise in the UK alongside #LongCovidKids

@Antonio_Caramia 🔽

This is of great concern, too

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More from @elisaperego78

Dr Elisa Perego Profile picture
5 Nov
Interesting to look at graphic 🔽 from @Join_ZOE on vaccine protection against covid for naive (=never infected) people vs those with vaccination + previous infection
A key issue to explore imo > does previous infection followed by #LongCovid change dynamics of protection?
🧵
This is a topic we have been discussing a lot in the #LongCovid community in view of reports of potential or proven immune dysfunction in Long Covid
I think immunity following vaccination in Long Covid is an area of research that need to be addressed urgently
Thanks @Know_HG for drawing my attention to the graphic
Read 4 tweets
Dr Elisa Perego Profile picture
5 Nov
Pediatric Covid-19 in Spain 🇪🇸
| analysis of the clinical spectrum of Covid in children seen at the emergency in 76 hospitals | cohort of n=1200 children under 18 | n=666 or 55% children hospitalized | n=123 or 18% required intensive care i.e. PICU 🧵

link.springer.com/article/10.100…
Median age: 4.7 years | 55% male | different levels of severity noted | from gastrointestinal symptoms to pulmonary involvement | MIS-C or multi-inflammatory syndrome diagnosed in 10% patients | over 20 pneumonia cases reported | most patients i.e. ~75% had no commorbities
8.5% had bacterial co-infection | 30% hospitalized patients ended up with severe complications | these included cardiac involvement in 11% ❗for example n=48 had myocardial involvement | and shock in 8% | 4 children needed ECMO i.e. mechanical blood oxygenation outside the body
Read 6 tweets
Dr Elisa Perego Profile picture
5 Nov
More on lung transplant after very severe covid | A last resource | An interview @JAMA_current with Dr Kim MD, and Dr Bharat MD, who performed the first post-covid double lung transplant in US | ~134 surgeries done in US up to May 2021 ❗

#LongCovid 🧵

jamanetwork.com/journals/jama/…
As @maureviv noted in our previous discussion (thanks!) patients considered for lung transplant must be young(ish), in pre-covid excellent health | 65 ys is often a cutoff | complex decision making for inclusion | 82 patients had ARDS | 48 fibrosis | 4 lung failure

#LongCovid
Some patients had been waiting for lung transplant on ECMO for like 5 months | ECMO is the procedure that oxygenate blood outside your body | in autopsies, lung damage from covid can be extreme: this prompted the decision to try lung transplant in the first place

#LongCovid
Read 6 tweets
Dr Elisa Perego Profile picture
4 Nov
V. good 🧵 on SARS-CoV-2 elimination | Delta increased transmissibility rate is used by some as an ideological excuse to push for "endemic covid" i.e. the "living with the virus like it's the flu" approach |
this is a political and not science-based argument imo 🧶
First, we have to remember that Delta is the product of weak, ideologically diriven policy that allowed SARS-CoV-2 unmitigated spread e.g. in India. Allowing further unleashed spread carries the risk of bringing new variants of concern about
The few countries that really put their efforts into crushing a Delta spread, reached their goal or came very close to it. Importantly, Delta is being brought into these countries from outside i.e. from the rest of the world, which didn't attempt to eliminate
Read 6 tweets
Dr Elisa Perego Profile picture
4 Nov
Almost 2% of the *entire* UK population reported suffering from #LongCovid in early October 2021

1.2 million people. Let's that sink in.

Official @ONS data out now. Growing numbers in children, of course, given the monstrous spike in pediatric and school-related covid cases
Data on children are of extreme concern as discussed by @Dr2NisreenAlwan

Tweet 🔽

In all of this, how many deaths has the UK recorded for covid? 141,000 official ones? Plus the excess deaths

And the healthcare collapse, impacting other diseases

#LongCovid is just part of this horrendous tragedy. Grief, pain and sorrow will loom large for decades to come
Read 4 tweets
Dr Elisa Perego Profile picture
2 Nov
#LongCovidKids in France 🇫🇷 @apresj20 | 201 pediatric patients | PCR + | most had mild disease at onset, often identified because of a cluster in their family | ~16% developed #LongCovid > symptoms lasting beyond 4 weeks from onset or appearing down disease course

#apresJ20 🧵
Median age: 9 ys | Acute phase ❗younger kids most likely to be hospitalized | two cases of viral pneumonia in a 4 and a 8 year-old + seven cases of bronchial issues > among only 6.5% were checked via x ray | 1 year-old had encephalitis for one month but recovered

#LongCovidKids
Most common #LongCovid symptoms noted: asthenia (significant fatigue), learning difficulties, headache | data obtained for 68% of original sample at 10--13 month follow up | no cases of MIS-C and myocarditis reported | symptomatic in acute phase more likely to have #LongCovidKids
Read 7 tweets

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