Cohort of 58 pediatric patients referred to hospital in the Farsi province | February--November 2020 | confirmed covid diagnosis | โ44% with reported #LongCovid three months after hospital discharge
26 children out of 58 reported #LongCovid symptoms | 55% female | age assessed 6--17 years | data collected via phone three months after hospital discharge | main symptoms noted include fatigue, shortness of breath, exercise intolerance, walking intolerance
other reported #LongCovid symptoms: sleep disruption, joint and muscle pain, cough, headache, excess sputum, chest pain, palpitations, dizziness, loss of smell (and others) | symptom severity as reported ranged from "mild" to disabling |
Symptoms in the acute phase included fever, cough, respiratory distress, muscle pain and diarrhoea | 17% needed intensive care in PICU | hospital stay length ranged from 1 to โ56 days | mean 7 days | 70% had no pre-existing conditions
My take aways from the study ๐ฅ including limitations: covid less dangerous in children than adults but it's *not* a benign disease in any age group โ| #LongCovidKids is not rare | it seems common post hospital discharge | it can be disabling in a number of cases
The study focused on hospitalization only | children under 6 were excluded because research was based on reported symptoms and not tests | in almost all cases, the phone interview was done to *parents* โ | we don't know directly, thus, how children experienced their symptoms
we have to wonder, for example, if symptoms reported as "mild" by parents and researchers were *always* experienced as such by the young patients โ | the study focused on a specific time point i.e. three months post discharge | we know however #LongCovid is a dynamic disease
not all potential #LongCovid symptoms were evaluated by the team and the study was symptom based | symptoms evaluated were only new symptoms after covid (point to be considered for children with pre-existing conditions like asthma)
Interesting to look at graphic ๐ฝ from @Join_ZOE on vaccine protection against covid for naive (=never infected) people vs those with vaccination + previous infection
A key issue to explore imo > does previous infection followed by #LongCovid change dynamics of protection?
๐งต
This is a topic we have been discussing a lot in the #LongCovid community in view of reports of potential or proven immune dysfunction in Long Covid
I think immunity following vaccination in Long Covid is an area of research that need to be addressed urgently
Thanks @Know_HG for drawing my attention to the graphic
Pediatric Covid-19 in Spain ๐ช๐ธ
| analysis of the clinical spectrum of Covid in children seen at the emergency in 76 hospitals | cohort of n=1200 children under 18 | n=666 or 55% children hospitalized | n=123 or 18% required intensive care i.e. PICU ๐งต
Median age: 4.7 years | 55% male | different levels of severity noted | from gastrointestinal symptoms to pulmonary involvement | MIS-C or multi-inflammatory syndrome diagnosed in 10% patients | over 20 pneumonia cases reported | most patients i.e. ~75% had no commorbities
8.5% had bacterial co-infection | 30% hospitalized patients ended up with severe complications | these included cardiac involvement in 11% โfor example n=48 had myocardial involvement | and shock in 8% | 4 children needed ECMO i.e. mechanical blood oxygenation outside the body
More on lung transplant after very severe covid | A last resource | An interview @JAMA_current with Dr Kim MD, and Dr Bharat MD, who performed the first post-covid double lung transplant in US | ~134 surgeries done in US up to May 2021 โ
As @maureviv noted in our previous discussion (thanks!) patients considered for lung transplant must be young(ish), in pre-covid excellent health | 65 ys is often a cutoff | complex decision making for inclusion | 82 patients had ARDS | 48 fibrosis | 4 lung failure
Some patients had been waiting for lung transplant on ECMO for like 5 months | ECMO is the procedure that oxygenate blood outside your body | in autopsies, lung damage from covid can be extreme: this prompted the decision to try lung transplant in the first place
Not complete! But enough biomedical research and clinical data to confirm what the @ONS from the UK are telling us. Children are impacted by Long Covid
V. good ๐งต on SARS-CoV-2 elimination | Delta increased transmissibility rate is used by some as an ideological excuse to push for "endemic covid" i.e. the "living with the virus like it's the flu" approach |
this is a political and not science-based argument imo ๐งถ
First, we have to remember that Delta is the product of weak, ideologically diriven policy that allowed SARS-CoV-2 unmitigated spread e.g. in India. Allowing further unleashed spread carries the risk of bringing new variants of concern about
The few countries that really put their efforts into crushing a Delta spread, reached their goal or came very close to it. Importantly, Delta is being brought into these countries from outside i.e. from the rest of the world, which didn't attempt to eliminate