Share this page!

Dave Feldman Profile picture
Twitter logo
14 Nov, 4 tweets, 3 min read
๐Ÿšจ๐Ÿšจ๐ŸšจBREAKING - $20k Analysis Effort๐Ÿšจ๐Ÿšจ๐Ÿšจ
1/2
Since my tweet last night, a donor has now come forward looking to fund ๐Ÿ‘‰๐Ÿ‘‰๐Ÿ‘‰$20,000๐Ÿ‘ˆ๐Ÿ‘ˆ๐Ÿ‘ˆ toward this effort for publication!!! ๐Ÿคฏ๐Ÿคฏ๐Ÿคฏ

Reaching out to any #DataScientist who is serious about making this happen.

(See next ๐Ÿ‘‡)
2/2
 ๐Ÿ‘‰๐Ÿ‘‰๐Ÿ‘‰ Here's our newly released post on this project: cholesterolcode.com/announcement-2โ€ฆ

If you're like me and feel this is waaaaay overdue, please help us find the Rockstar(s) who can make this a reality!
Hey #UnitedKingdom docs like @lowcarbGP and @DrScottMurray -- know anyone data scientists on #UKBiobank who'd be interested in this project? ๐Ÿ‘†๐Ÿ‘†๐Ÿ‘†
Hey @garytaubes, @bigfatsurprise, @davidasinclair, and @ProfTimNoakes -- know of any #DataScientists looking to help us out on this?

$20,000 should go a long way to finally get a major longitudinal analysis of (โฌ†๏ธLDL+โฌ†๏ธHDL+โฌ‡๏ธtriglycerides) vs All Cause Mortality.

โ€ข โ€ข โ€ข

Missing some Tweet in this thread? You can try to force a refresh
ใ€€

Keep Current with Dave Feldman

Dave Feldman Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @DaveKeto

Dave Feldman Profile picture
3 Nov
1/ This is especially important timing.

As many of you know, we're conducting a study on #LMHRs (link later in thread) who not only have extremely high #LDL #Cholesterol, but many (likely most) have diets quite contrary to this advice by the @American_Heart.

Let's unpack...
2/ First, and most importantly, we do not know what the outcome of this prospective study is. So while I'll be outlining commonalities we observe with #LMHRs, this isn't an explicit endorsement of the diet nor any altered lipid levels as a result.

With that said...
3/ We have a lot of data between our standing survey, submissions to CholesterolCode.com, and CC and LMHR Facebook groups (7.7k and 7.5k members, respectively).

Diets are often:
1) Low to no fruits & veg
2) Low to no grains
3) High animal protein
4) Low in plant oils
Read 6 tweets
Dave Feldman Profile picture
22 Oct
1/ ๐Ÿ‘‰ "HDL Triglycerides"
or rather HDL-TG
-- As in, triglycerides onboard HDL particles

โ†—๏ธ Highly associated with: total TG, glycerol, fatty liver index. โ†˜๏ธOpposite w/ HDL-C/-P

And ofc ๐Ÿ‘‰"Patients with carotid plaques also showed higher HDL-TG."...

pubmed.ncbi.nlm.nih.gov/31252694/
2/ @josefagirona, @lluismasana et al conclude the abstract with:

"HDL-TG should be considered a biomarker of metabolic and cardiovascular risk and could be a marker of HDL dysfunction."

If I can offer a different hypothesis (again, consistent with the #LipidEnergyModel)...
3/ Consider these HDL particles with higher levels of triglycerides aren't really that unique.

They more likely a downstream result of metabolic dysfunction as opposed to a distinct species of particle.
Read 8 tweets
Dave Feldman Profile picture
12 Oct
1/ Posting this hypothesis for posterity:

I now suspect #PlantBasedLowCarb (PBLC) isn't as low carb as originally thought.

Before getting started in this thread, I should emphasize I wouldn't consider this a good or bad thing in and of itself, but it is of interest, ofc... Image
2/ Moreover, I've regularly pointed to people following my work who are both (1) very interested in a low carb diet, but (2) would prefer to keep their #LDL low to consider PBLC as a "third option", as I commonly see it associates with this outcome.

Now to my hypothesis...
3/ PBLC generally has two major features separating it from "typical" #keto/#lchf:

1) More fat sourced from mono and polyunsaturated fatty acids (M/PUFA) instead of saturated fatty acids (SFA)

2) A lot more soluble and insoluble fiber via plants
Read 11 tweets
Dave Feldman Profile picture
25 Sep
1/ New #LipidEnergyModel video on ANGPTL proteins via @nicknorwitz

And a few added thoughts...

ANGPTLs are *all* inhibitors. They are applying the breaks to the Lipoprotein Lipase (LPL) in particular.

So consider this analogy...
2/ Imagine a room full of people at tables being served with trays of food regularly coming from the kitchen moved around the room by waiters.

No one is particularly famished, but they aren't especially full either, so they are absently taking food off the trays to maintain...
3/ However, a few guests at one table leave to get some exercise and return quit hungry.

And here's the catch: You can't tell specific people to do specific things (including the waiters), but you can say things to the entire room. Is there a way to solve this puzzle?
Read 5 tweets
Dave Feldman Profile picture
16 Sep
1/ Okay, finally getting around to this experiment video by @ScepticalDoctor

Naturally, this has many things I'm interested in -->
- N=1
- #Lipids (esp #Cholesterol)
- and not least of all, Anna and I have many respectful, kind debates (more of that plz, #NutritionTwitter)
2/ "But this experiment is mainly for entertainment purposes. Self experiments like this are irrelevant from a scientific perspective."

Unsurprisingly, I do disagree on this wording. I think it's fair to say self-experiments have "limited" relevance (depending on design)...
3/ ... But a well designed N=1 can provide quite a lot of scientific value, even if primarily hypothesis-generating.
Read 15 tweets
Dave Feldman Profile picture
5 Sep
1/ Yes, my answer to the poll by @nicknorwitz was "Gain 4% body fat". And honestly, it was a pretty easy one when compared to the others.

But to be fair, I also have quite a bit of direct data on this in particular... let's unpack...
2/ First, if you didn't already know this about me, in 2018 I literally gained almost 20lbs of fat for the Weight Gain Experiment. cholesterolcode.com/weight-gain-exโ€ฆ

(As an aside, I realize now I did presentations on the findings for this experiment, but didn't do a write up. Bad Dave!)
3/ But spoiler alert -- my total and LDL cholesterol did indeed go down where having gained weight and back up where having lost it.

To be sure, I think there are thresholds to "active fat gain/loss" vs standing, stable fat mass, but we'll save that for another thread.
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Thank you for your support!

Follow Us on Twitter!

Like this author's thread?

Get emails when @DaveKeto has new unrolls!

Check out other threads from @DaveKeto!

Read all threads by @DaveKeto

:(