If you ingest antioxidants, consider this: Free radicals (ROS) activate immune cells that kill cancer. Explains the anti-tumor effect of METFORMIN, a type 2 diabetes drug that may also slow aging 💪 1/ eurekalert.org/multimedia/807… 
MitoTEMPO, an antioxidant scavenger of mitochondrial superoxide, abolished the antitumor effect of METFORMIN in mice. Maybe regular anti-oxidants, such as vitamin C, prevent METFORMIN from inhibiting cancer... 2/
The MitoTEMPO data suggests METFORMIN's anti-cancer effect stems from mitochondrial ROS ->"mitohormesis"⚡️You can also induce mitohormesis via EXERCISE (⬇️O2) or hyperbaric O2 therapy (⬆️O2). Does HBOT slow cancer? Yep! This 2021 paper @SciReports nature.com/articles/s4159…🌪️ 3/
Interestingly, glucose supplementation in mice amplified the anti-tumor effects of METFORMIN. Increased glucose uptake seems to activate anti-cancer immune cells. Effect was abolished by treating with an inhibitor of glucose metabolism, 2-deoxyglucose. 4/
Model: METFORMIN -> mtROS -> Glut-1 (glucose transporter) -> Nrf2 -> mTORC1 (target of rapamycin) -> CD8TIL immune cell activation ⚕️ Another ticked box for mitohormesis. Thanks Michael Ristow for this hypothesis (2013)🥇 nature.com/articles/nm.36…
Short term, high Vit C may be beneficial for variety of ailments: mdpi.com/2072-6694/13/6…
Long-term though, in large studies, Vit C (and E) seem to have no immediate or long-term effects on cancer academic.oup.com/ajcn/article/1…
In context of METFORMIN? Unknown.
Long-term though, in large studies, Vit C (and E) seem to have no immediate or long-term effects on cancer academic.oup.com/ajcn/article/1…
In context of METFORMIN? Unknown.
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